Results 71 to 80 of about 197,789 (295)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Core-sensitive Mixed f/g-mode of the Sun Predicted by Wave Topology and Hydrodynamical Simulation
The Astrophysical Journal LettersHelioseismology has revolutionized our understanding of the Sun by analyzing its global oscillation modes. However, the solar core remains elusive, limiting a full understanding of its evolution.
Arthur Le Saux +4 more
doaj +1 more source
The Impact of Hydrodynamic Mixing on Supernova Progenitors
, 2005 Recent multidimensional hydrodynamic simulations have demonstrated the importance of hydrodynamic motions in the convective boundary and radiative regions of stars to transport of energy, momentum, and composition. The impact of these processes increases
Casey Meakin +5 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Reverse Shock Revisited in Cassiopeia A with Chandra
The Astrophysical JournalUsing data from the Chandra X-ray Observatory, we revisit the reverse shock in the supernova remnant (SNR) Cassiopeia A. Based on spectroscopy of a series of annuli in the northwest (NW) and southeast (SE), we get the radial profiles of the S/Si K α line
Yin Wu, X. J. Yang
doaj +1 more source
Optimising the global detection of solar-like oscillations
Astronomy & AstrophysicsContext. A well-established method exists for predicting the detectability of solar-like oscillations that has seen extensive application supporting target selection strategies for space-based photometric missions.
Lund Mikkel N., Chaplin William J.
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Astrophysical JournalBlue large-amplitude pulsators (BLAPs) are a recently discovered group of hot pulsating stars whose evolutionary status remains uncertain. Their proposed progenitors are either ≃0.3 M _⊙ shell H-burning stars or ≃1.0 M _⊙ core He-burning stars, both ...
Susmita Das +2 more
doaj +1 more source
Stellarator physics evaluation studies
, 1983 Stellarator/torsatron configurations with a wide range of parameters have been evaluated and compared in terms of their vacuum field topology, magnetohydrodynamic equilibrium and stability, and guiding center orbit confinement. The torsatron configurations are found to be the most suitable choice for a near-term physics experiment.
B. A. Carreras, J. H. Harris, J. A. Rome
openaire +2 more sources