Results 101 to 110 of about 14,785 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Improving the distances of post-AGB objects in the Milky Way [PDF]

, 2016
Post-AGB (PAGB) stars are short-lived, low-intermediate mass objects transitioning from the asymptotic giant branch (AGB) to the white dwarf (WD) phase.
Vickers, SB, Bojicic, Ivan S. (R16652), Quentin A Parker, Parker, Quentin A., Owers, MS, Frew, DJ, David J Frew, Frew, David J., Parker, QA, Bojicic, IS, Matt S Owers, Ivan S Bojičič, Shane B Vickers, Vickers, Shane B., Owers, Matt S.   +14 more
core   +1 more source

Lux: A Generative, Multioutput, Latent-variable Model for Astronomical Data with Noisy Labels

The Astronomical Journal
The large volume of spectroscopic data available now and from near-future surveys will enable high-dimensional measurements of stellar parameters and properties. Current methods for determining stellar labels from spectra use physics-driven models, which
Danny Horta, Adrian M. Price-Whelan, David W. Hogg, Melissa K. Ness, Andrew R. Casey   +4 more
doaj   +1 more source

Spectropolarimetry for Discerning Geometry and Structure in Circumstellar Media of Hot Massive Stars

Galaxies
Spectropolarimetric techniques are a mainstay of astrophysical inquiry, ranging from Solar System objects to the Cosmic Background Radiation. This review highlights applications of stellar polarimetry for massive hot stars, particularly in the context of
Richard Ignace, Kenneth G. Gayley, Roberto Casini, Paul Scowen, Christiana Erba, Jeremy Drake   +5 more
doaj   +1 more source

Observational clues to the physics at the magnetosphere in young stellar objects

EPJ Web of Conferences, 2014
Classical T Tauri stars offer an excellent laboratory to study the accretion process and star-disk interaction, which define the transfer of mass and angular momentum in the system. The interaction takes place very close to the star, in a region of about
Alencar Silvia H. P.
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The Power of Asteroseismology for Early Stellar Evolution

Frontiers in Astronomy and Space Sciences, 2019
Stars are the building blocks of planetary systems, clusters, associations, and galaxies. The evolution of stars is driven by physical processes in their interiors making theory of stellar interior structure and evolution an important ingredient of ...
Konstanze Zwintz
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

WASP-80b has a dayside within the T-dwarf range [PDF]

, 2015
AHMJT is a Swiss National Science Foundation (SNSF) fellow under grant number P300P2-147773. MG and EJ are Research Associates at the F.R.S-FNRS; LD received the support the support of the F.R.I.A. fund of the FNRS.
Collier Cameron, Andrew, Pollacco, Don, Smith, Alexis M. S., Ehrenreich, D., Triaud, AHMJ, Ribas, Ignasi, Delrez, L, Ribas, I, Hellier, Coel, Ribas, I., Herrero, Enrique, Udry, S., Maxted, PFL, Delrez, L., Maxted, P. F. L., Smith, A. M. S., Smith, AMS, Delrez, Laetitia, Cameron, AC, Demory, B.-O., Smalley, Barry, Queloz, Didier, Heng, Keving, Jehin, E., Udry, Stephane, Herrero, E., Demory, B-O, Anderson, DR, Anderson, David R., Pollacco, D, Lendl, Monika, Queloz, D., Pollacco, D., Gillon, M, Gillon, M., Herrero, E, Ehrenreich, D, Smith, Alexis Michael Sheridan, Heng, K., Hellier, C., Heng, K, Heng, Kevin, Jehin, E, Triaud, A. H. M. J., Gillon, Michael, Jehin, Emmanuel, Lendl, M, Triaud, Amaury H. M. J., Smalley, B., Smalley, B, Demory, Brice-Olivier, Hellier, C, Triaud, A. H. M. J.; id_orcid, Ehrenreich, David, Cameron, Andrew Collier, Lendl, M., Collier Cameron, A., Maxted, Pierre F. L., Anderson, D. R., Udry, S, Queloz, D   +60 more
core   +1 more source

The Absolute Age of Milky Way Globular Clusters

The Astrophysical Journal
Globular clusters (GCs) provide statistically significant coeval populations of stars spanning various evolutionary stages, allowing robust constraints on stellar evolution model parameters and ages.
Jiaqi (Martin) Ying, Brian Chaboyer, Michael Boylan-Kolchin, Daniel R. Weisz, Rowan Goebel-Bain   +4 more
doaj   +1 more source