Results 41 to 50 of about 112,697 (340)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
, 2011 In this work the latitude dependent stellar spot rotation is investigated based on dynamo models. The maps of the magnetic pressure at the surface from the dynamo calculations are treated similarly to the temperature maps obtained using Doppler imaging ...
Elstner, D., Korhonen, H.
core +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
The Directly Imaged Exoplanet Host Star 51 Eridani is a Gamma Doradus Pulsator
The Astrophysical Journal, 2022 51 Eri is well known for hosting a directly imaged giant planet and for its membership to the β Pictoris moving group. Using 2 minute cadence photometry from the Transiting Exoplanet Survey Satellite (TESS), we detect multiperiodic variability in 51 Eri ...
Aldo G. Sepulveda +5 more
doaj +1 more source
Studying Stellar Rotation and Convection [PDF]
, 2013 Based on the lecture notes of a school titled "Tides in Astronomy and Astrophysics" that brought together students and researchers, this book focuses on the fundamental theories of tides at different scales of the universe - from tiny satellites to whole galaxies - and on the most recent developments.
Goupil, Marie-José +4 more
openaire +3 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Differential Rotation of CoRoT Stars and a Kepler Binary Star from Starspot Transit Mapping
The Astrophysical JournalWhile direct magnetic field measurements are rare for slowly rotating stars, spots observed during planetary transits provide a potential indicator of magnetic activity on stellar surfaces.
Adriana Valio +2 more
doaj +1 more source
Kepler main-sequence solar-like stars: surface rotation and magnetic-activity evolution
Frontiers in Astronomy and Space SciencesWhile the mission’s primary goal was focused on exoplanet detection and characterization, Kepler made and continues to make extraordinary advances in stellar physics. Stellar rotation and magnetic activity are no exceptions.
Ângela R. G. Santos +8 more
doaj +1 more source
Photometric magnetic-activity metrics tested with the Sun: application to Kepler M dwarfs
Journal of Space Weather and Space Climate, 2014 The Kepler mission has been providing high-quality photometric data leading to many breakthroughs in the exoplanet search and in stellar physics. Stellar magnetic activity results from the interaction between rotation, convection, and magnetic field ...
Mathur Savita +3 more
doaj +1 more source
THE STELLAR-ACTIVITY-ROTATION RELATIONSHIP AND THE EVOLUTION OF STELLAR DYNAMOS [PDF]
The Astrophysical Journal, 2011 Accepted for publication in ApJ.
Nicholas J. Wright +3 more
openaire +4 more sources