Results 51 to 60 of about 2,893 (217)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Accurate and Robust Stellar Rotation Periods Catalog for 82771 Kepler Stars Using Deep Learning

The Astronomical Journal
We propose a new framework to predict stellar properties from light curves. We analyze the light-curve data from the Kepler space mission and develop a novel tool for deriving the stellar rotation periods for main-sequence stars.
Ilay Kamai, Hagai B. Perets
doaj   +1 more source

Star–planet interaction in the Proxima system

Astronomy & Astrophysics
Aims. We search for evidence of star–planet magnetic interactions in the nearby Proxima Centauri planetary system using high-quality, high-spectral-resolution optical observations spanning three years. Methods.
Zapatero Osorio M. R., Béjar V. J. S., Suárez Mascareño A., Rebolo R., Cristiani S., Micela G., Miles-Páez P. A., Santos N. C., Pallé E., González Hernández J. I., Damasso M., Castro-González A., Martins C. J. A. P., Pepe F., Sozzetti A., Lavie B., Rodrigues J.   +16 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Photometric magnetic-activity metrics tested with the Sun: application to Kepler M dwarfs

Journal of Space Weather and Space Climate, 2014
The Kepler mission has been providing high-quality photometric data leading to many breakthroughs in the exoplanet search and in stellar physics. Stellar magnetic activity results from the interaction between rotation, convection, and magnetic field ...
Mathur Savita, Salabert David, García Rafael A., Ceillier Tugdual   +3 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

TESS Asteroseismology of β Hydri: A Subgiant with a Born-again Dynamo

The Astrophysical Journal
The solar-type subgiant β Hyi has long been studied as an old analog of the Sun. Although the rotation period has never been measured directly, it was estimated to be near 27 days.
Travis S. Metcalfe, Jennifer L. van Saders, Daniel Huber, Derek Buzasi, Rafael A. García, Keivan G. Stassun, Sarbani Basu, Sylvain N. Breton, Zachary R. Claytor, Enrico Corsaro, Martin B. Nielsen, J. M. Joel Ong, Nicholas Saunders, Amalie Stokholm, Timothy R. Bedding   +14 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source