Results 51 to 60 of about 116,076 (286)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Differential Rotation of CoRoT Stars and a Kepler Binary Star from Starspot Transit Mapping

The Astrophysical Journal
While direct magnetic field measurements are rare for slowly rotating stars, spots observed during planetary transits provide a potential indicator of magnetic activity on stellar surfaces.
Adriana Valio, Alexandre Araújo, Fabian Menezes   +2 more
doaj   +1 more source

Kepler main-sequence solar-like stars: surface rotation and magnetic-activity evolution

Frontiers in Astronomy and Space Sciences
While the mission’s primary goal was focused on exoplanet detection and characterization, Kepler made and continues to make extraordinary advances in stellar physics. Stellar rotation and magnetic activity are no exceptions.
Ângela R. G. Santos, Diego Godoy-Rivera, Diego Godoy-Rivera, Adam J. Finley, Savita Mathur, Savita Mathur, Rafael A. García, Sylvain N. Breton, Anne-Marie Broomhall   +8 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The California-Kepler Survey. XI. A Survey of Chromospheric Activity through the Lens of Precise Stellar Properties

The Astrophysical Journal
Surveys of exoplanet host stars are valuable tools for assessing population level trends in exoplanets, and their outputs can include stellar ages, activity, and rotation periods.
Howard Isaacson, Stephen R. Kane, Brad Carter, Andrew W. Howard, Lauren Weiss, Erik A. Petigura, Benjamin Fulton   +6 more
doaj   +1 more source

Investigating variation of latitudinal stellar spot rotation and its relation to the real stellar surface rotation

, 2011
In this work the latitude dependent stellar spot rotation is investigated based on dynamo models. The maps of the magnetic pressure at the surface from the dynamo calculations are treated similarly to the temperature maps obtained using Doppler imaging ...
Elstner, D., Korhonen, H.
core   +1 more source

The Factory and The Beehive I. Rotation Periods For Low-Mass Stars in Praesepe [PDF]

, 2011
Stellar rotation periods measured from single-age populations are critical for investigating how stellar angular momentum content evolves over time, how that evolution depends on mass, and how rotation influences the stellar dynamo and the magnetically ...
Adam Kraus, Baraffe, Barnes, Barnes, Barnes, Barnes, Browning, Covey, Covey, Delfosse, Dotter, Dovi Poznanski, Efron, Eran O. Ofek, Feigelson, Giampapa, Irwin, Irwin, Jenna J. Lemonias, Joshua S. Bloom, Kevin R. Covey, Kiraga, Kraus, Krishnamurthi, Law, Mamajek, Mansi M. Kasliwal, Marcel A. Agüeros, Meibom, Meibom, Monet, Natasha Batalha, Nicholas M. Law, Peter E. Nugent, Robert M. Quimby, S. Bradley Cenko, Shrinivas R. Kulkarni, Skrutskie, Soderblom, Stauffer, Steele, Stoughton, Terndrup, West, York   +44 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Toward a Self-consistent Hydrodynamical Model of the Solar Tachocline

The Astrophysical Journal
The solar tachocline is a thin internal boundary layer in the Sun located between the differentially rotating convection zone and the uniformly rotating region of the radiative interior beneath. E. A. Spiegel & J. P.
P. Garaud, D. O. Gough, L. I. Matilsky
doaj   +1 more source