Results 41 to 50 of about 2,893 (217)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The Relationship of Stellar Radius Inflation to Rotation and Magnetic Starspots at 10–670 Myr

The Astrophysical Journal Letters
Active, low-mass stars are widely observed to have radii that are larger than predicted by standard stellar models. Proposed mechanisms for this radius inflation generally involve stellar magnetism, either in the form of added pressure support in the ...
Lyra Cao, Keivan G. Stassun
doaj   +1 more source

The rotation–magnetism relationship in solar-type stars

Astronomy & Astrophysics
Context. The rotation–activity relationship of G-type stars results from surface magnetic fields emerging from the interior. How the magnetic flux and its emergence rate scale with rotation rate are not well understood, both observationally and ...
Işık Emre, Solanki Sami K., Krivova Natalie A., Shapiro Alexander I.   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quiet Please: Detrending Radial Velocity Variations from Stellar Activity with a Physically Motivated Spot Model

The Astronomical Journal
For solar-type stars, spots and their associated magnetic regions induce radial velocity perturbations through the Doppler rotation signal and the suppression of convective blueshift, collectively known as rotation modulation.
Jared C. Siegel, Samuel Halverson, Jacob K. Luhn, Lily L. Zhao, Khaled Al Moulla, Paul Robertson, Chad F. Bender, Ryan C. Terrien, Arpita Roy, Suvrath Mahadevan, Fred Hearty, Joe P. Ninan, Jason T. Wright, Eric B. Ford, Christian Schwab, Guðmundur Stefánsson, Cullen H. Blake, Michael W. McElwain   +17 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Meta-analysis of Photometric and Asteroseismic Measurements of Stellar Rotation Periods: The Lomb–Scargle Periodogram, Autocorrelation Function, and Wavelet and Rotational Splitting Analysis for 92 Kepler Asteroseismic Targets

The Astrophysical Journal, 2022
We perform intensity variability analyses (photometric analyses: the Lomb–Scargle periodogram, autocorrelation, and wavelet) and asteroseismic analysis of 92 Kepler solar-like main-sequence stars to understand the reliability of the measured stellar ...
Yuting Lu, Othman Benomar, Shoya Kamiaka, Yasushi Suto   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stellar Cycle Variability in Mount Wilson Stars and Dynamo Models: Rotation Rate and Dynamo Number Dependency

The Astrophysical Journal
Similar to the solar cycle, the magnetic cycles of other solar-type stars are also variable. How the variability of the stellar cycle changes with the rotation rate or the dynamo number is valuable information for understanding the stellar dynamo process.
Suyog Garg, Rohan B. Mandrai, Bidya Binay Karak   +2 more
doaj   +1 more source