Results 121 to 130 of about 2,711,256 (365)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

2 SINGLE INTRASPHINCTERIC INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS TO TREAT STRESS URINARY INCONTINENCE AFTER RADICAL PROSTATECTOMY: A PILOT STUDY

Continence, 2022
M Moussa, B Dabboucy, A Papatsoris, Y Moussa, Y Fares, A Dellis, H Issa, H Bailly, M Abou Chakra   +8 more
doaj   +1 more source

Therapeutic Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage [PDF]

, 2017
Producción CientíficaLimbal stem cells are responsible for the continuous renewal of the corneal epithelium. The destruction or dysfunction of these stem cells or their niche induces limbal stem cell deficiency (LSCD) leading to visual loss, chronic pain,
Calonge Cano, Margarita, Galindo de la Rosa, Sara, Herreras Cantalapiedra, José María, López Paniagua, Marina, Mata Sampedro, Ana de la, Nieto Miguel, Teresa, Plata Cordero, María, Rey, Esther   +7 more
core   +2 more sources

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment [PDF]

, 2018
Federico Bocci, Larisa Gearhart-Serna, Marcelo Boareto, Mariana P.C. Ribeiro, Eshel Ben‐Jacob, Gayathri R. Devi, Herbert Levine, José N. Onuchic, Mohit Kumar Jolly   +8 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

State of the Art in the Standardization of Stromal Vascular Fraction Processing

Biomolecules
Stromal Vascular Fraction (SVF) has gained significant attention in clinical applications due to its regenerative and anti-inflammatory properties. Initially identified decades ago, SVF is derived from adipose tissue and has been increasingly utilized in
Martina Cremona, Matteo Gallazzi, Giulio Rusconi, Luca Mariotta, Mauro Gola, Gianni Soldati   +5 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Cell Communication and Signaling, 2019
Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by ...
Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang, Han Liu   +16 more
doaj   +1 more source

Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells [PDF]

, 2008
Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time. Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing many human diseases ...
Garg, Abhishek D.
core  

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy [PDF]

, 2018
Diogo Mosqueira, Ingra Mannhardt, Jamie R. Bhagwan, Katarzyna Lis-Slimak, Puspita Anggraini Katili, Elizabeth Scott, Mustafa Hassan, Maksymilian Prondzynski, Stephen C. Harmer, Andrew Tinker, James G.W. Smith, Lucie Carrier, Philip M. Williams, Daniel J. Gaffney, Thomas Eschenhagen, Arne Hansen, Chris Denning   +16 more
openalex   +1 more source