Results 121 to 130 of about 1,492,484 (317)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Skin graft with dermis and appendages generated in vivo by cell competition

Nature Communications
Autologous skin grafting is a standard treatment for skin defects such as burns. No artificial skin substitutes are functionally equivalent to autologous skin grafts. The cultured epidermis lacks the dermis and does not engraft deep wounds.
Hisato Nagano, Naoaki Mizuno, Hideyuki Sato, Eiji Mizutani, Ayaka Yanagida, Mayuko Kano, Mariko Kasai, Hiromi Yamamoto, Motoo Watanabe, Fabian Suchy, Hideki Masaki, Hiromitsu Nakauchi   +11 more
doaj   +1 more source

Derivation of embryonic stem cells across avian species [PDF]

Xi Chen, Zheng Guo, Xinyi Tong, Xizi Wang, Xugeng Liu, Hiroki Nagai, Ping Wu, Jiayi Lu, David Huss, Martin Tran, Carol Readhead, C.-S. Wu, Lin Cao, Yixin Huang, Zhao‐Chong Zeng, Fan Feng, Nima Adhami, Sirjan Mor, Rusty Lansford, Cheng‐Ming Chuong, Guojun Sheng, Carlos Lois, Qi-Long Ying   +22 more
openalex   +1 more source

Successful management of concurrent acquired hemophilia A and a lupus anticoagulant in a pediatric hematopoietic stem cell transplant patient [PDF]

, 2018
LaQuita M. Jones, Christopher E. Dandoy, Sonata Jodele, Kasiani C. Myers, Lori Luchtman‐Jones, Charles T. Quinn, Eric S. Mullins, Javier El‐Bietar   +7 more
openalex   +1 more source

Supplementary Data from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

, 2023
Stephanie Z. Xie, Kerstin B. Kaufmann, Weijia Wang, Michelle Chan‐Seng‐Yue, Olga I. Gan, Elisa Laurenti, Laura García‐Prat, Shin‐ichiro Takayanagi, Stanley W.K. Ng, Changjiang Xu, Andy G.X. Zeng, Liqing Jin, Jessica McLeod, Elvin Wagenblast, Amanda Mitchell, James A. Kennedy, Qiang Liu, Héléna Boutzen, Melissa Kleinau, Joseph Jargstorf, Gareth D. Holmes, Yang Zhang, Véronique Voisin, Gary D. Bader, Jean Wang, Yusuf A. Hannun, Chiara Luberto, Timm Schroeder, Mark D. Minden, John E. Dick   +29 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Total Ischemic Time as an Independent Predictor of Response to Stem Cell Therapy in Patients with ST Segment Elevation Myocardial Infarction [PDF]

, 2014
Mary Yuling Lim, Zekeriya Arslan, Chunyan Cai, Christopher Y. Kim, Yong‐Jian Geng, Ali E. Denktas   +5 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells [PDF]

, 1993
DM Bodine, NE Seidel, KM Zsebo, Donald Orlic   +3 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source