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Gastrointestinal Stem Cells I. Pancreatic stem cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
The transplantation of islets isolated from donor pancreas has renewed the interest in cell therapy for the treatment of diabetes. In addition, the capacity that stem cells have to differentiate into a wide variety of cell types makes their use ideal to generate β-cells for transplantation therapies.
Soria, Bernat   +2 more
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Stem cell factor

Journal of Leukocyte Biology, 1995
Abstract Stem cell factor (SCF) is the ligand for the tyrosine kinase receptor okit, which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro, SCF synergizes with other growth factors, such as granulocyte colony-stimulating factor (G–CSF), granulocyte macrophage–colony-stimulating factor, and interleukin-3
I K, McNiece, R A, Briddell
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Testicular Stem Cells

Seminars in Reproductive Medicine, 2006
Spermatogenesis originates from a constantly renewing population of testicular stem cells (TSCs). The existence of TSCs offers clinically relevant options for preservation and reestablishment of male fertility. Therefore, it is essential to understand the fundamental biology of TSCs and the basic mechanisms of self-renewal, differentiation, and ...
Goossens, Ellen, Tournaye, Herman
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Gastrointestinal Stem Cells. II. Intestinal stem cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein ...
Matthew, Bjerknes, Hazel, Cheng
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Neural Stem Cells

2019
Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad spectrum of clinical diseases, including stroke, psychiatric illnesses such as fetal alcohol spectrum disorders, and cancer.
Tuazon J. P.   +6 more
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Mesenchymal Stem Cells

Journal of Orthopaedic Research, 1991
AbstractBone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end‐stage cells involved with ...
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“Mesenchymal” Stem Cells

Annual Review of Cell and Developmental Biology, 2014
Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. This cell coincides with a specific type of bone marrow perivascular cell.
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Stem Cell Bioengineering

Annual Review of Biomedical Engineering, 2001
▪ Abstract  Tissue engineering and cellular therapies, either on their own or in combination with therapeutic gene delivery, have the potential to significantly impact medicine. Implementation of technologies based on these approaches requires a readily available source of cells for the generation of cells and tissues outside a living body.
P W, Zandstra, A, Nagy
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Hæmatopoietic Stem Cells

Nature, 1964
NORMAL haematopoiesis is initiated and maintained by haematopoietic stem cells. These cells perform two functions: (1) they differentiate into mature haemic elements, and (2) they maintain and renew the population of stem cells. It is these stem cells which seed, differentiate and reproduce, thus effecting successful haematopoietic transplants.
J P, LEWIS, F E, TROBAUGH
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Leukaemic stem cells

Transfusion Medicine, 2003
Summary.  All haemopoietic cell lineages arise from multipotential self‐renewing stem cells that give rise to committed progenitor cells. These progenitor cells subsequently differentiate into more lineage‐committed cells with a restricted range of plasticity. A hierarchical order is considered to exist, where lineage commitment and differentiation are
A, Blair, D H, Pamphilon
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