Results 61 to 70 of about 13,537,858 (412)
Cells, 2023 Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasizes ...
Burak Toprakhisar +2 more
doaj +1 more source
Stem cell decisions:A twist of fate or a niche market? [PDF]
, 2014 Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Anderson +112 more
core +2 more sources
Stem Cell Research & Therapy, 2016 Background The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g., fetal liver and cord blood), or ...
Sapana Jalnapurkar +4 more
doaj +1 more source
Using single-cell entropy to describe the dynamics of reprogramming and differentiation of induced pluripotent stem cells [PDF]
, 2020 Induced pluripotent stem cells (iPSCs) provide a great model to study the process of reprogramming and differentiation of stem cells. Single-cell RNA sequencing (scRNA-seq) enables us to investigate the reprogramming process at single-cell level. Here, we introduce single-cell entropy (scEntropy) as a macroscopic variable to quantify the cellular ...
arxiv +1 more source
The individuality of stem cells [PDF]
BMC Biology, 2011 Lander BMC Biology 2011, 9:40 http://www.biomedcentral.com/1741-7007/9/40 CO M M E N T Open Access The individuality of stem cells Arthur D Lander* When a group of immigrants moves into a community in large numbers, so much attention is usually focused on how they are different – in language, customs, appearance, and so on – from everyone else, that ...
openaire +7 more sources
Mesenchymal Stem Cell Migration and Tissue Repair
Cells, 2019 Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine.
Xiaorong Fu +5 more
semanticscholar +1 more source
Current Biology, 2003 AbstractBritain is publicly and privately backing stem-cell research but worries continue about the legal framework scientists face in undergoing such work ...
openaire +4 more sources
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
eLife, 2014 Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum +9 more
doaj +1 more source
Ethical and Safety Issues of Stem Cell-Based Therapy
International Journal of Medical Sciences, 2018 Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders.
V. Volarevic +9 more
semanticscholar +1 more source
Nature Communications, 2019 Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri +3 more
doaj +1 more source