Results 81 to 90 of about 12,666,103 (318)

Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesis

Scientific Reports, 2017
A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear.
Lizhi Leng, Qi Ouyang, Xiangyi Kong, Fei Gong, Changfu Lu, Lei Zhao, Yun Shi, Dehua Cheng, Liang Hu, Guangxiu Lu, Ge Lin   +10 more
doaj   +1 more source

The hematopoietic stem cell niche in homeostasis and disease [PDF]

, 2015
Laura M. Calvi, Daniel C. Link
openalex   +1 more source

Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine

, 2021
Jinxiu Yang, Shiyi Li, Leren He, Minliang Chen   +3 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Nature Cell Biology, 2017
Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient ...
John C. Schell, D. Wisidagama, C. Bensard, Helong Zhao, Peng Wei, J. Tanner, A. Flores, J. Mohlman, Lise K Sorensen, Christian S Earl, Kristofor A Olson, Ren Miao, T. Cameron Waller, D. Delker, P. Kanth, Lei Jiang, R. Deberardinis, M. Bronner, Dean Y Li, J. Cox, H. Christofk, W. Lowry, C. Thummel, J. Rutter   +23 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

2 SINGLE INTRASPHINCTERIC INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS TO TREAT STRESS URINARY INCONTINENCE AFTER RADICAL PROSTATECTOMY: A PILOT STUDY

Continence, 2022
M Moussa, B Dabboucy, A Papatsoris, Y Moussa, Y Fares, A Dellis, H Issa, H Bailly, M Abou Chakra   +8 more
doaj   +1 more source

Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting [PDF]

, 2015
Veerakumar Balasubramaniyan, Brian Vaillant, Shuzhen Wang, Joy Gumin, M. Elena Butalid, Ke Sai, Farah Mukheef, Se Hoon Kim, H. W. G. M. Boddeke, Frederick F. Lang, Kenneth Aldape, Erik P. Sulman, Krishna Bhat, Howard Colman   +13 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

State of the Art in the Standardization of Stromal Vascular Fraction Processing

Biomolecules
Stromal Vascular Fraction (SVF) has gained significant attention in clinical applications due to its regenerative and anti-inflammatory properties. Initially identified decades ago, SVF is derived from adipose tissue and has been increasingly utilized in
Martina Cremona, Matteo Gallazzi, Giulio Rusconi, Luca Mariotta, Mauro Gola, Gianni Soldati   +5 more
doaj   +1 more source