Results 81 to 90 of about 1,492,484 (317)

Genipin‐crosslinked decellularized annulus fibrosus hydrogels induces tissue‐specific differentiation of bone mesenchymal stem cells and intervertebral disc regeneration [PDF]

, 2020
Yizhong Peng, Donghua Huang, Jinye Li, Sheng Liu, Xiangcheng Qing, Zengwu Shao   +5 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

SINGLE INTRACAVERNOUS INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS VERSUS A SINGLE HIGH DOSE OF PLATELET RICH PLASMA TO IMPROVE ERECTILE DYSFUNCTION: A COMPARATIVE STUDY

Continence, 2023
H Bailly, M Abou Chakra, F Schill, B Dabboucy, C Khalil, M Lorenz, N Rodehutskors, J Boaz, M Jida, N El Beayni, K Ismail, E Hanna, L Hage, A Abo Yassine, G Delavar, A Popescu, M Moussa   +16 more
doaj   +1 more source

Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress

Cell Communication and Signaling
Background Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation.
Jinxin Lu, Xiaoyu Zhang, Keyu Su, Huandong Luo, Congcong Liu, Yuqing Yang, Bin He, Cenxin Wang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Peixuan Meng, Dekang Lv, Chunli Wang, Keith W. Kelley, Ling Wang, Bai Cui, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance [PDF]

, 2007
N.J. Robertson, Frances A. Brook, Richard L. Gardner, Stephen Cobbold, Herman Waldmann, Paul J. Fairchild   +5 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

2 SINGLE INTRASPHINCTERIC INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS TO TREAT STRESS URINARY INCONTINENCE AFTER RADICAL PROSTATECTOMY: A PILOT STUDY

Continence, 2022
M Moussa, B Dabboucy, A Papatsoris, Y Moussa, Y Fares, A Dellis, H Issa, H Bailly, M Abou Chakra   +8 more
doaj   +1 more source

State of the Art in the Standardization of Stromal Vascular Fraction Processing

Biomolecules
Stromal Vascular Fraction (SVF) has gained significant attention in clinical applications due to its regenerative and anti-inflammatory properties. Initially identified decades ago, SVF is derived from adipose tissue and has been increasingly utilized in
Martina Cremona, Matteo Gallazzi, Giulio Rusconi, Luca Mariotta, Mauro Gola, Gianni Soldati   +5 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source