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Adult haematopoietic stem cell niches
Nature Reviews Immunology, 2017Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of ...
Genevieve M, Crane +2 more
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Nature, 2001
The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings.
A, Spradling +2 more
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The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings.
A, Spradling +2 more
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2010
The adult stem cells, or tissue-specific stem cells, are essential for maintaining tissue homeostasis and commonly reside in specific local microenvironment named niche. The niche keeps stem cells in multipotent/unipotent state and prevents them from precocious differentiation, and in some cases positions them to undergo asymmetric division to produce ...
Pei Wen, Pei Sun, Rongwen Xi
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The adult stem cells, or tissue-specific stem cells, are essential for maintaining tissue homeostasis and commonly reside in specific local microenvironment named niche. The niche keeps stem cells in multipotent/unipotent state and prevents them from precocious differentiation, and in some cases positions them to undergo asymmetric division to produce ...
Pei Wen, Pei Sun, Rongwen Xi
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Experimental Cell Research, 2007
Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between
Mitsiadis TA +4 more
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Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between
Mitsiadis TA +4 more
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2009
Niche dependence is an outstanding property of several stem cell types. This dependence has been unequivocally proven, and molecularly analyzed, in Drosophila gonads. The various types of mammalian stem cell niches, and their cellular and molecular structure are discussed.
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Niche dependence is an outstanding property of several stem cell types. This dependence has been unequivocally proven, and molecularly analyzed, in Drosophila gonads. The various types of mammalian stem cell niches, and their cellular and molecular structure are discussed.
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The spermatogonial stem cell niche
Microscopy Research and Technique, 2009AbstractSpermatogonial stem cells (SSCs; As spermatogonia) and their direct descendants (Apr and Aal spermatogonia) are preferentially located in those areas of the seminiferous tubules that border on the interstitial tissue. Fewer of these cells are present in tubule areas directly bordering on another tubule.
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Stem Cell Niche Versus Cancer Stem Cell Niche – Differences and Similarities
2009The organization of normal tissues and organs is thought to be based on stem cells, which are present as a small proportion of the total tissue. Stem cells in turn absolutely require supporting structures to maintain their self-renewal properties and such structures are termed niches.
Bruce C. Baguley, Graeme J. Finlay
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Hematopoietic Stem Cell Niches
2009The hematopoietic stem cell (HSC) is probably the best characterized somatic stem cell and is still the only one regularly used in clinical practice. Nevertheless, expansion of HSCs in vitro has been surprisingly unsuccessful, limiting their full therapeutic potential.
Anne Wilson, Andreas Trumpp
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Local and systemic mechanisms that control the hair follicle stem cell niche
Nature Reviews Molecular Cell Biology, 2023Bing Zhang
exaly
Pulp Stem Cells: Niches of Stem Cells
2014Stem cells are pluripotent or monopotent cells obtained from the embryo (ESCs) or from the adult (ASCs), or they may be induced (iPSCs). Positive markers are STRO-1, CD13, CD44, CD24, CD29, CD73, CD90, CD105, CD106, CD146, Oct4, Nanog, and beta-2 integrin. In the dental pulp in young rats, about 0.40 % may be stem cells, whereas only 0.11 % is found in
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