Results 51 to 60 of about 193,899 (265)

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake [PDF]

, 2012
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Abdulmetin Dursun, Atul K. Bhan, BD Simons, C Beard, CM McCay, D Nakada, DA Guertin, David M. Sabatini, DD Sarbassov, DE Cohen, DT Breault, Dudley W. Lamming, E Sangiorgi, G. Petur Nielsen, GG Altmann, HJ Snippert, J Chen, Khristian E. Bauer-Rowe, Kivanc Birsoy, L Bondolfi, L Zhu, Lawrence R. Zukerberg, LE O’Brien, LG van der Flier, M Podesta, Mari Mino-Kenudson, Martin Selig, N Barker, N Takeda, NY Kalaany, OH Yilmaz, OH Yilmaz, Pekka Katajisto, RP Ertl, S Dunel-Erb, S Hempenstall, S Sengupta, Shomit Sengupta, SR Spindler, T Sato, T Sato, V Marsh, V. Onur Yilmaz, Vikram Deshpande, Yetis Gültekin, Ömer H. Yilmaz   +45 more
core   +2 more sources

Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens. [PDF]

PLoS ONE, 2009
In vivo, stem cell fate is regulated by local microenvironmental parameters. Governing parameters in this stem cell niche include soluble factors, extra-cellular matrix, and cell-cell interactions.
Raheem Peerani, Kento Onishi, Alborz Mahdavi, Eugenia Kumacheva, Peter W Zandstra   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The regenerative nidi of the locust midgut as a model to study epithelial cell differentiation from stem cells [PDF]

, 2006
A better knowledge of the regulatory mechanisms involved in stem cell proliferation and/or differentiation could reveal new methods for the treatment of some diseases.
Illa-Bochac, I. (Irineu), Montuenga-Badia, L.M. (Luis M.)   +1 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells [PDF]

, 2019
The stem cell niche is a complex local signaling microenvironment that sustains stem cell activity during organ maintenance and regeneration. The mammary gland niche must support its associated stem cells while also responding to systemic hormonal ...
Beachy, P.A., Cai, S., Clarke, M.F., Kalisky, T., Lim, A., Lu, W.-J., Shin, K., Zhao, C.   +7 more
core   +1 more source

Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

eLife, 2014
Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem ...
Aiguo Tian, Jin Jiang
doaj   +1 more source

Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

eLife, 2020
Stem cells reside in and rely upon their niche to maintain stemness but must balance self-renewal with the production of daughters that leave the niche to differentiate. We discovered a mechanism of stem cell niche exit in the canonical C. elegans distal
Kacy L Gordon, Jay W Zussman, Xin Li, Camille Miller, David R Sherwood   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Direct measurement of local oxygen concentration in the bone marrow of live animals [PDF]

, 2014
Characterizing how the microenvironment, or niche, regulates stem cell activity is central to understanding stem cell biology and to developing strategies for therapeutic manipulation of stem cells1. Low oxygen tension (hypoxia) is commonly thought to be
A Mohyeldin, Alyssa Klein, AY Lebedev, AY Lebedev, C Lo Celso, C Nombela-Arrieta, Charles P. Lin, Clemens Alt, DA Sipkins, Daniel Côté, David T. Scadden, DC Chow, DC Chow, DJ Ceradini, Emmanuel Roussakis, Francesca Ferraro, I Veilleux, IB Mazo, J Lecoq, JL Mignone, JMJ Vanderkooi, Joel A. Spencer, Judith M. Runnels, Juwell Wu, K Parmar, K Takubo, KE Lee, LDL Wang, LE Sinks, LM Calvi, Luke J. Mortensen, MAM Lichtman, MJ Kiel, MWM Dewhirst, OS Finikova, Raphaël Turcotte, RD Unwin, Rushdia Yusuf, S Lymperi, S Méndez-Ferrer, S Sakadžić, Sergei A. Vinogradov, SMS Kazmi, T Suda, TV Esipova, Walid Zaher, Y Kunisaki   +46 more
core   +3 more sources