Results 31 to 40 of about 86,985 (264)
Stem Cell Reports, 2018 Summary: The regulatory mechanisms that control neural stem cell (NSC) activation in the adult ventricular-subventricular zone (V-SVZ) stem cell niche have been the focus of intense investigation, yet how the niche first develops and organizes is poorly ...
Xiwei Shan +3 more
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Hacking the stem cell niche [PDF]
Blood, 2017 In this issue of Blood , Stoddart et al think outside of the stem cell “box” to identify a therapeutically tractable pathway in del(5q) myelodysplastic syndrome (MDS), through blocking pathologically activated Wnt signaling arising within the stem cell niche ...
Steven W. Lane, Florian H. Heidel
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Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System
ResearchResistin plays an important role in the pathophysiology of obesity-mediated insulin resistance in mice. However, the biology of resistin in humans is quite different from that in rodents. Therefore, the association between resistin and insulin resistance
Han-Mo Yang +11 more
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Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis
Cell Reports, 2015 The extracellular matrix plays an essential role for stem cell differentiation and niche homeostasis. Yet, the origin and mechanism of assembly of the stem cell niche microenvironment remain poorly characterized.
Véronique Van De Bor +7 more
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Bioengineering, 2021 The recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in
David H. Ramos-Rodriguez +3 more
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E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. [PDF]
PLoS ONE, 2010 Many adult stem cells reside in a special microenvironment known as the niche, where they receive essential signals that specify stem cell identity.
Mayu Inaba +4 more
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Niche formation and function in developing tissue: studies from the Drosophila ovary
Cell Communication and Signaling, 2023 Adult stem cells have a unique ability to self-renew and to generate differentiated daughter cells that are required in the body tissues. The identity of adult stem cells is maintained by extrinsic signals from other cell types, known as niche cells ...
Jian Jin, Ting Zhao
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Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis.
PLoS Genetics, 2023 The function of the stem cell system is supported by a stereotypical shape of the niche structure. In Drosophila ovarian germarium, somatic cap cells form a dish-like niche structure that allows only two or three germ-line stem cells (GSCs) reside in the
Kiichiro Taniguchi, Tatsushi Igaki
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Stem Cell Niches: Famished Paneth Cells, Gluttonous Stem Cells [PDF]
Current Biology, 2012 Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
Kim, Tae-Hee, Shivdasani, Ramesh A.
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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