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Regenerative medicine for male infertility: A focus on stem cell niche injury models
Biomedical Journal, 2022 Stem and progenitor cells located within stem cell niches maintain the renewal and regeneration of tissues and organs throughout the life of an adult organism.
Georgy Sagaradze +5 more
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Neural stem cell niche heterogeneity [PDF]
Seminars in Cell & Developmental Biology, 2019 In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell ...
Julia P. Andreotti +10 more
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Frontiers in Cardiovascular Medicine, 2016 Cell therapy in myocardial infarction (MI) is an innovative strategy that is regarded as a rescue therapy to repair the damaged myocardium and to promote neovascularization for the ischemic border zone.
Jeehoon Kang +7 more
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Smart Materials in Medicine, 2021 Repair and reconstruction of critical-size bone defects have been challenges in the clinic for many years. Stem cell therapy is a promising strategy for these dilemmas, and induced pluripotent stem cells (iPSCs) have emerged as competent candidates of ...
Zhangfan Ding +4 more
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The hematopoietic stem cell niche [PDF]
Frontiers in Bioscience, 2012 Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC
Park, Dongsu +2 more
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Cellular population dynamics control the robustness of the stem cell niche
Biology Open, 2015 Within populations of cells, fate decisions are controlled by an indeterminate combination of cell-intrinsic and cell-extrinsic factors. In the case of stem cells, the stem cell niche is believed to maintain ‘stemness’ through communication and ...
Adam L. MacLean +2 more
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Sensory nerves in the spotlight of the stem cell niche
Stem Cells Translational Medicine, 2021 Niches are specialized tissue microenvironments that control stem cells functioning. The bone marrow mesenchymal stem cell niche defines a location within the marrow in which mesenchymal stem cells are retained and produce new cells throughout life ...
Caroline C. Picoli +13 more
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Frontiers in Oncology, 2022 Cancer stem cells are thought to be the main drivers of tumorigenesis for malignancies such as glioblastoma (GBM). They are maintained through a close relationship with the tumor vasculature.
Funto A. Akindona +6 more
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Patient-derived induced pluripotent stem cells for models of cancer and cancer stem cell research
Journal of the Formosan Medical Association, 2018 Induced pluripotent stem cells (iPSCs) are embryonic stem cell-like cells reprogrammed from somatic cells by four transcription factors, OCT4, SOX2, KLF4 and c-MYC.
Hsiao-Mei Chao, Edward Chern
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Cell Reports, 2018 Summary: Homeostasis in adult tissues depends on the precise regulation of stem cells and their surrounding microenvironments, or niches. Here, we show that the cell cycle inhibitor and tumor suppressor Retinoblastoma (RB) is a critical regulator of ...
Leah J. Greenspan, Erika L. Matunis
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