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Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyIntestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
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Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance [PDF]
Cell Communication and SignalingThe stem cell niche plays a pivotal non–cell-autonomous role in maintaining stem cell function, yet it can be disrupted by tissue injury or cancer therapy. Here, we propose that dying cells induced by external insults actively construct a novel, enhanced
Mingjie Jiang +7 more
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Ocular surface microbiota: Ophthalmic infectious disease and probiotics
Frontiers in Microbiology, 2022 Recently, increasing studies have emphasized the importance of commensal bacteria in humans, including microbiota in the oral cavity, gut, vagina, or skin.
Ming-Cheng Chiang +2 more
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Hepatic stem cell niches [PDF]
Journal of Clinical Investigation, 2013 Stem cell niches are special microenvironments that maintain stem cells and control their behavior to ensure tissue homeostasis and regeneration throughout life. The liver has a high regenerative capacity that involves stem/progenitor cells when the proliferation of hepatocytes is impaired.
Claus, Kordes, Dieter, Häussinger
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KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state
Journal of Hematology & Oncology, 2021 Background Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance.
Jin-Woo Lee +16 more
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Artificial Stem Cell Niches [PDF]
Advanced Materials, 2009 AbstractStem cells are characterized by their dual ability to reproduce themselves (self‐renew) and specialize (differentiate), yielding a plethora of daughter cells that maintain and regenerate tissues. In contrast to their embryonic counterparts, adult stem cells retain their unique functions only if they are in intimate contact with an instructive ...
Matthias P, Lutolf, Helen M, Blau
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Biomaterials Research, 2023 Background Although vasospastic angina (VSA) is known to be caused by coronary artery spasm, no study has fully elucidated the exact underlying mechanism. Moreover, in order to confirm VSA, patients should undergo invasive coronary angiography with spasm
Han-Mo Yang +14 more
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Targeting the stem cell niche micro-environment as therapeutic strategies in aging
Frontiers in Cell and Developmental Biology, 2023 Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to their self-renewal capacity and differentiation potential, ASCs have the potential to be used in regenerative medicine. Their survival, quiescence, and activation are
Raheleh Farahzadi +3 more
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Stem Cell Niche Microenvironment: Review [PDF]
Bioengineering, 2021 The cornea comprises a pool of self-regenerating epithelial cells that are crucial to preserving clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a specialized stem cell niche (SCN), are crucial for the survival of the human corneal epithelium.
Mohamed Abdul-Al +4 more
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The Vascular Stem Cell Niche [PDF]
Journal of Cardiovascular Translational Research, 2012 Stem cells in adult organs reside in specialized niches that regulate their proliferation and differentiation. Investigations during the last few years have unveiled a regulatory role for blood vessels in these microenvironments. Mesenchymal stem cells (MSCs) are located surrounding capillaries in a variety of tissues and have the capacity to ...
Gómez-Gaviro, Maria Victoria +3 more
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