Results 51 to 60 of about 86,985 (264)

Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins [PDF]

Journal of Histochemistry & Cytochemistry, 2018
In glioblastoma, a fraction of malignant cells consists of therapy-resistant glioblastoma stem cells (GSCs) residing in protective niches that recapitulate hematopoietic stem cell (HSC) niches in bone marrow. We have previously shown that HSC niche proteins stromal cell–derived factor-1α (SDF-1α), C-X-C chemokine receptor type 4 (CXCR4), osteopontin ...
Hira, Vashendriya V. V., Wormer, Jill R., Kakar, Hala, Breznik, Barbara, van der Swaan, Britt, Hulsbos, Renske, Tigchelaar, Wikky, Tonar, Zbynek, Khurshed, Mohammed, Molenaar, Remco J., van Noorden, Cornelis J. F.   +10 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mimicking stem cell niches to increase stem cell expansion [PDF]

Current Opinion in Biotechnology, 2008
Niches regulate lineage-specific stem cell self-renewal versus differentiation in vivo and are composed of supportive cells and extracellular matrix components arranged in a three-dimensional topography of controlled stiffness in the presence of oxygen and growth factor gradients.
Shara M, Dellatore, A Sofia, Garcia, William M, Miller   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Isolation of PRRX1-positive adult pituitary stem/progenitor cells from the marginal cell layer of the mouse anterior lobe

Stem Cell Research, 2021
We recently suggested that paired-related homeobox 1 (PRRX1) and sex-determining region Y-box 2 (SOX2) double-positive (PRRX1/SOX2-positive) cells are pituitary stem/progenitor cells. The present study aimed to isolate PRRX1-positive cells located in the
Aran Shintani, Masashi Higuchi
doaj   +1 more source

Stem Cell Regulation by the Haemopoietic Stem Cell Niche [PDF]

Cell Cycle, 2005
Both cellular as well as extracellular matrix components of the stem cell microenvironment, or niche, are critical in stem cell regulation. Recent data highlight a central role for osteoblasts and their by-product osteopontin as a key part of the hematopoietic stem cell (HSC) niche.
David N, Haylock, Susan K, Nilsson
openaire   +2 more sources

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Non-cell-autonomous regulation of testicular stem cell niche homeostasis by the 20S proteasome core particle through cell adhesion and cyclin proteins [PDF]

Open Biology
The Drosophila stem cell niche harbours two principal stem cell populations: germline stem cells (GSCs) and cyst stem cells (CySCs), whose self-renewal and differentiation are stringently governed by niche-derived regulatory factors.
Jiaxin Li, Chenyu Wang, Weiyi Qian, Lei He, Qiuru Huang, Junwei Zhao, Ziyu Cao, Yuqi Huang, Yanting Wang, Xinda Wang, Yuwen Du, Xinyang Li, Guyue Zhu, Youran Li, Jun Yu, Xiaofang Tan, Zhiran Li   +16 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stem Cells: Specifying Stem-Cell Niches in the Worm [PDF]

Current Biology, 2006
Recent work has shown that components of the Wnt signaling pathway directly activate a homeodomain transcription factor so as to specify the cell fate that provides niche function to germline stem cells in the nematode Caenorhabditis elegans.
Van Hoffelen, Samantha, Herman, Michael A.   +1 more
openaire   +2 more sources