Results 61 to 70 of about 817,109 (355)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A systems biology approach to identify niche determinants of cellular phenotypes

Stem Cell Research, 2016
Recent reports indicate a dominant role for cellular microenvironment or niche for stably maintaining cellular phenotypic states. Identification of key niche mediated signaling that maintains stem cells in specific phenotypic states remains a challenge ...
Srikanth Ravichandran, Satoshi Okawa, Susana Martínez Arbas, Antonio del Sol   +3 more
doaj   +1 more source

Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins [PDF]

Journal of Histochemistry & Cytochemistry, 2018
In glioblastoma, a fraction of malignant cells consists of therapy-resistant glioblastoma stem cells (GSCs) residing in protective niches that recapitulate hematopoietic stem cell (HSC) niches in bone marrow. We have previously shown that HSC niche proteins stromal cell–derived factor-1α (SDF-1α), C-X-C chemokine receptor type 4 (CXCR4), osteopontin ...
Hira, Vashendriya V. V., Wormer, Jill R., Kakar, Hala, Breznik, Barbara, van der Swaan, Britt, Hulsbos, Renske, Tigchelaar, Wikky, Tonar, Zbynek, Khurshed, Mohammed, Molenaar, Remco J., van Noorden, Cornelis J. F.   +10 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

Nature Communications, 2018
A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell function, the role of the extra-cellular matrix ...
Shanti sree Sandeepani Rayagiri, D. Ranaldi, Alexander Raven, Nur Izzah Farhana Mohamad Azhar, O. Lefebvre, P. Zammit, A. Borycki   +6 more
semanticscholar   +1 more source

Mimicking stem cell niches to increase stem cell expansion [PDF]

Current Opinion in Biotechnology, 2008
Niches regulate lineage-specific stem cell self-renewal versus differentiation in vivo and are composed of supportive cells and extracellular matrix components arranged in a three-dimensional topography of controlled stiffness in the presence of oxygen and growth factor gradients.
Shara M, Dellatore, A Sofia, Garcia, William M, Miller   +2 more
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

Nature Communications, 2022
Asymmetric signaling and organization in the stem cell niche determine cell fates. Here the authors show that polarized contact-dependent signaling through specialized cytonemes forms the basis of niche-specific asymmetric signaling and stem cell ...
Akshay Patel, Yicong Wu, Xiaofei Han, Yijun Su, Tim Maugel, Hari Shroff, Sougata Roy   +6 more
doaj   +1 more source

Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation [PDF]

, 2022
Julianne Smith, Brittany Cordova, Brian Richardson, Kelsey F. Christo, Jordan Campanelli, Alyssia V. Broncano, Jonathan Chen, Juyeun Lee, Scott J. Cameron, Justin D. Lathia, Wendy A. Goodman, Mark J. Cameron, Amar Desai   +12 more
openalex   +1 more source

Stem Cell Regulation by the Haemopoietic Stem Cell Niche [PDF]

Cell Cycle, 2005
Both cellular as well as extracellular matrix components of the stem cell microenvironment, or niche, are critical in stem cell regulation. Recent data highlight a central role for osteoblasts and their by-product osteopontin as a key part of the hematopoietic stem cell (HSC) niche.
David N, Haylock, Susan K, Nilsson
openaire   +2 more sources