Results 81 to 90 of about 195,866 (192)

Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

Nature Communications, 2022
Asymmetric signaling and organization in the stem cell niche determine cell fates. Here the authors show that polarized contact-dependent signaling through specialized cytonemes forms the basis of niche-specific asymmetric signaling and stem cell ...
Akshay Patel, Yicong Wu, Xiaofei Han, Yijun Su, Tim Maugel, Hari Shroff, Sougata Roy   +6 more
doaj   +1 more source

MicroRNA MIR396 regulates the switch between stem cells and transit-amplifying cells in arabidopsis roots [PDF]

, 2015
To ensure an adequate organ mass, the daughters of stem cells progress through a transit-amplifying phase displaying rapid cell division cycles before differentiating.
Benfey, Philip N., Breakfield, Natalie W., Cools, Toon, De Veylder, Lieven, Debernardi, Juan Manuel, Ercoli, María Florencia, Mecchia, Martin Alejandro, Palatnik, Javier Fernando, Rodriguez Virasoro, Ramiro Esteban, Sabatini, Martín   +9 more
core   +3 more sources

Cancer stem cell and niche [PDF]

Frontiers in Bioscience, 2010
Recent research on cancer has generated a new model for cancer growth-cancer stem cell model. This model can explain the inefficiency of conventional therapy. Tumor tissue, like normal tissue, is continuously repopulated from pools of self-renewing stem cells growing in a "niche", which is made up of a specialized vascular bed of endothelial cells ...
openaire   +2 more sources

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
A M Thompson, AM Thompson, C Calabrese, C Ginestier, C Scheel, C Sheridan, CE Eyler, CL Chaffer, CM Fillmore, E Charafe-Jauffret, E Resetkova, EY Tan, F Vaillant, G Farnie, G Kristiansen, G Rappa, H Harrison, H Korkaya, J Stingl, J Zhou, JC Lawson, JM Rosen, K Engelmann, K He, K Murray, M Al-Hajj, M Boylan, M Christgen, M Kok, M Pajic, M V Appleyard, MA Ahmed, ME Prince, MH Wright, MJ Grimshaw, MV Appleyard, O Al-Assar, O Leis, O Moussa, P J Coates, P Kabos, R Nenutil, S Bao, S Liu, SY Kim, SY Park, T Tanei, TM Phillips, WW Hwang-Verslues, Y Liu   +49 more
core   +4 more sources

Tenascins in stem cell niches

Matrix Biology, 2014
Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated.
Chiquet-Ehrismann Ruth, Orend Gertraud, Chiquet Matthias, Tucker Richard P, Midwood Kim S   +4 more
openaire   +6 more sources

Laminin is the ECM niche for trophoblast stem cells

Life Science Alliance, 2020
Laminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin. The niche is a specialized microenvironment for tissue stem cells in vivo. It has long been emphasized
Daiji Kiyozumi, Itsuko Nakano, Ryoko Sato-Nishiuchi, Satoshi Tanaka, Kiyotoshi Sekiguchi   +4 more
doaj   +1 more source

Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo [PDF]

, 2008
Stem cells are maintained in an undifferentiated state by signals from their microenvironment, the stem cell niche. Despite its central role for organogenesis throughout the plant's life, little is known about how niche development is regulated in the ...
Hinze, A., Jurgens, G., Laux, T., Takada, S., Tucker, E., Tucker, M.   +5 more
core   +1 more source

Hematopoietic stem cell niches [PDF]

SCIENTIA SINICA Vitae, 2017
Hematopoietic stem cells (HSC) reside at the apex of the hematopoietic hierarchy, with self-renewal and differentiation potential, and are widely used in clinic. Studies in the past few decades have confirmed that the functional characteristics of HSC are not only controlled by intrinsic factors, but also supported and nourished by extrinsic ...
Hui CHENG, Tao CHENG
openaire   +1 more source

Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin [PDF]

, 2014
The transcription factor Oct4 (Pou5f1) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore, Oct4 expression might identify somatic stem cell populations with inherent multipotent potential or a propensity ...
Bauersachs, Johann, Ha, Teng-Cheong, Limbourg, Anne, Limbourg, Florian P, Lozanovski, Vladimir J, Maetzig, Tobias, Naim, Hassan Y, Napp, L Christian, Schambach, Axel, Schnabel, Sabine   +9 more
core   +2 more sources

Stem cell niche: Dynamic neighbor of stem cells

European Journal of Cell Biology, 2019
Stem cell niche is a specialized and dynamic microenvironment around the stem cells which plays a critical role in maintaining the stemness properties of stem cells. Over the years, advancement in the research activity has revealed the various important aspects of stem cell niche including cell-cell interaction, cell-extracellular matrix interaction, a
Anshuman, Singh, C B, Yadav, N, Tabassum, A K, Bajpeyee, V, Verma   +4 more
openaire   +2 more sources