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Stem cell therapy-based approaches in experimental endometriosis: a systematic review [PDF]
Background Stem cell-based therapies have emerged as a promising approach for endometriosis due to their regenerative and immunomodulatory properties. Although numerous preclinical studies have reported beneficial effects, no systematic synthesis has yet
Isabel Suárez-Carrasco +5 more
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Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune and inflammatory disease with multiple organs and systems involved such as the kidney, lung, brain and the hematopoietic system. Although increased knowledge of the disease pathogenesis has improved treatment options, current immunosuppressive therapies have failed to ...
Yuan, Xinran, Sun, Lingyun
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Hyperconcentrated Platelet-Rich Plasma (High-PRP) for the treatment of a non-healing ulcer of the lateral malleolus: a case report and literature review [PDF]
Clinical Case: A 77-year-old man with a history of hypertension (stage 2) and multiple phalanx amputations of the right hand due to Raynaud's disease, referred to our regenerative medicine Clinic for a cutaneous ulceration (of arterial origin) of the ...
M. Fernández Viña +4 more
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Menstrual blood-derived stromal cells: insights into their secretome in acute hypoxia conditions
Background Despite constant advances in regenerative medicine, the closure of chronic wounds is still challenging. Therapeutic approaches using locally administered MSCs have been considered a promising option.
María Ángeles de Pedro +7 more
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High-dose chemotherapy and autologous stem-cell transplant (HDC/ASCT) is standard treatment for chemosensitive relapsed classical Hodgkin lymphoma, although outcomes of high-risk relapse (HRR) patients remain suboptimal.
Yago Nieto +32 more
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Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones
Background CRISPR/Cas9 editing systems are currently used to generate mutations in a particular gene to mimic a genetic disorder in vitro. Such “disease in a dish” models based on human pluripotent stem cells (hPSCs) offer the opportunity to have access ...
Elie Frank +9 more
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Stem Cell Therapy Is Proarrhythmic [PDF]
Stem cell therapy appears to be a promising modality for myocardial repair of both hearts that are post myocardial infarction (MI) and those with other forms of structural cardiac disease (eg, congestive heart failure). In fact, recent experimental and clinical work has suggested that stem cell therapy contributes to cardiac regeneration. Unfortunately
Ester, Macia, Penelope A, Boyden
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Stem Cell Therapy in Cardiology [PDF]
Cell therapy provides one of the most important solutions to the unmet need for new treatments in cardiovascular disease. This area of research has undergone a rapid translation into humans, with the bone marrow mononuclear cell predominating as the cell type with most clinical data.
Fizzah Aziz, Choudry, Anthony, Mathur
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While chimeric antigen receptor (CAR)-T-cell therapy has demonstrated remarkable effectiveness in the treatment of B-cell lymphomas and leukemias, research on T-cell malignancies is still limited.
Xueer Xu +13 more
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Introduction to Stem Cell Therapy [PDF]
Stem cells have the ability to differentiate into specific cell types. The 2 defining characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult cell type. There are 2 major classes of stem cells: pluripotent cells, which can become any cell in the adult body, and multipotent cells, which are ...
Jesse K, Biehl, Brenda, Russell
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