Results 1 to 10 of about 8,398,186 (316)

Stem cell therapy-based approaches in experimental endometriosis: a systematic review [PDF]

Reproductive Biology and Endocrinology
Background Stem cell-based therapies have emerged as a promising approach for endometriosis due to their regenerative and immunomodulatory properties. Although numerous preclinical studies have reported beneficial effects, no systematic synthesis has yet
Isabel Suárez-Carrasco, María Ángeles De Pedro, María Pulido, Verónica Álvarez, Francisco Miguel Sánchez-Margallo, Esther López   +5 more
doaj   +2 more sources

Hyperconcentrated Platelet-Rich Plasma (High-PRP) for the treatment of a non-healing ulcer of the lateral malleolus: a case report and literature review [PDF]

CellR4, 2020
Clinical Case: A 77-year-old man with a history of hypertension (stage 2) and multiple phalanx amputations of the right hand due to Raynaud's disease, referred to our regenerative medicine Clinic for a cutaneous ulceration (of arterial origin) of the ...
M. Fernández Viña, L. Camozzi, M. Spitaleri, R. Fernández Viña, G. Reinchisi   +4 more
doaj   +1 more source

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis

Haematologica, 2021
High-dose chemotherapy and autologous stem-cell transplant (HDC/ASCT) is standard treatment for chemosensitive relapsed classical Hodgkin lymphoma, although outcomes of high-risk relapse (HRR) patients remain suboptimal.
Yago Nieto, Stephen Gruschkus, Benigno C. Valdez, Roy B. Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J. Shpall, Borje S. Andersson   +32 more
doaj   +1 more source

Menstrual blood-derived stromal cells: insights into their secretome in acute hypoxia conditions

Molecular Medicine, 2023
Background Despite constant advances in regenerative medicine, the closure of chronic wounds is still challenging. Therapeutic approaches using locally administered MSCs have been considered a promising option.
María Ángeles de Pedro, María Pulido, Verónica Álvarez, Federica Marinaro, Ana María Marchena, Francisco Miguel Sánchez-Margallo, Javier G. Casado, Esther López   +7 more
doaj   +1 more source

Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones

Stem Cell Research & Therapy, 2023
Background CRISPR/Cas9 editing systems are currently used to generate mutations in a particular gene to mimic a genetic disorder in vitro. Such “disease in a dish” models based on human pluripotent stem cells (hPSCs) offer the opportunity to have access ...
Elie Frank, Michel Cailleret, Constantin Nelep, Pascal Fragner, Jérome Polentes, Elise Herardot, Lina El Kassar, Karine Giraud-Triboult, Christelle Monville, Karim Ben M’Barek   +9 more
doaj   +1 more source

HLA Fully-Mismatched Sibling-Derived CD7 CAR-T Therapy Bridging to Haploidentical Hematopoietic Stem Cell Transplantation for Hepatosplenic γδ T-cell Lymphoma

Cell Transplantation, 2023
While chimeric antigen receptor (CAR)-T-cell therapy has demonstrated remarkable effectiveness in the treatment of B-cell lymphomas and leukemias, research on T-cell malignancies is still limited.
Xueer Xu, Cheng Zu, Mingming Zhang, Pingnan Xiao, Ruimin Hong, Jingjing Feng, Huijun Xu, Jiazhen Cui, Jian Yu, Jimin Shi, Guoqing Wei, Alex H. Chang, He Huang, Yongxian Hu   +13 more
doaj   +1 more source

Identification of very early inflammatory markers in a porcine myocardial infarction model

BMC Veterinary Research, 2019
Background Acute myocardial infarction (AMI) is one of the most deleterious conditions leading to cardiovascular diseases and mortality. The importance of an early and accurate diagnosis assures immediate medical treatments, which are fundamental to ...
Esther López, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Rebeca Blázquez, Federica Marinaro, Ana Abad, Helena Martín, Claudia Báez, Virginia Blanco, Verónica Crisóstomo, Javier García Casado   +10 more
doaj   +1 more source

The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

Cells, 2021
The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues.
Margot Jarrige, Elie Frank, Elise Herardot, Sabrina Martineau, Annabelle Darle, Manon Benabides, Sophie Domingues, Olivier Chose, Walter Habeler, Judith Lorant, Christine Baldeschi, Cécile Martinat, Christelle Monville, Lise Morizur, Karim Ben M’Barek   +14 more
doaj   +1 more source

Identifying microRNA determinants of human myelopoiesis

Scientific Reports, 2018
Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and ...
Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko   +7 more
doaj   +1 more source

The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

Cancer Cell International, 2023
Background Chimeric antigen receptor (CAR) T-cells have revolutionized the treatment of CD19- and B-cell maturation antigen-positive haematological malignancies.
Gerard J. Chu, Charles G. Bailey, Rajini Nagarajah, Sharon M. Sagnella, Stephen Adelstein, John E. J. Rasko   +5 more
doaj   +1 more source