Results 101 to 110 of about 2,855,746 (355)

Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application

Stem Cells International, 2016
Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in ...
A. Bakopoulou, I. About
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Signs of immune dysregulation in second-trimester maternal blood RNA profiles in late-onset preeclampsia

Scientific Reports
Preeclampsia (PE) is a hypertensive disorder that affects 5% of pregnancies. It is characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. We investigated maternal second-trimester peripheral blood gene expression profiles to
Gamze Yazgeldi Gunaydin, Sini Ezer, Juho Wedenoja, Katri Räikkönen, Juha Kere, Satu Wedenoja, Shintaro Katayama   +6 more
doaj   +1 more source

Ethical and Regulatory Challenges with Autologous Adult Stem Cells:A Comparative Review of International Regulations [PDF]

, 2015
Cell and tissue-based products, such as autologous adult stem cells, are being prescribed by physicians across the world for diseases and illnesses that they have neither been approved for or been demonstrated as safe and effective in formal clinical ...
Lysaght, T, Lysaght, Tamra, Sipp, Douglas, Kerridge, I, Porter, G, Sipp, D, Porter, Gerard, Capps, Benjamin J., Kerridge, Ian, Capps, BJ   +9 more
core   +1 more source

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro

Stem cell research & therapeutics, 2018
Adult mesenchymal stem cells (MSCs) hold great promise for regenerative medicine because of their self-renewal, multipotency, and trophic and immunosuppressive effects.
Y. Yang, Courtney R. Ogando, Carmine Wang See, Tsui-Yun Chang, G. Barabino   +4 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Isolation of multipotent cells from human term placenta

, 2008
[[abstract]]Current sources of stem cells include embryonic stem cells (ESCs) and adult stem cells (ASCs). However, concerns exist with either source: ESCs, with their significant ethical considerations, tumorigenicity, and paucity of cell lines; and ...
Yen, BL; Huang, HI; Chien, CC; Jui, HY; Ko, BS; Yao, M; Shun, CT; Yen, ML; Lee, MC; Chen, YC
core   +1 more source

Adipose-derived mesenchymal stromal/stem cells : tissue localization, characterization, and heterogeneity [PDF]

, 2012
Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared to other sources. It is easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose-derived mesenchymal ...
Helmut Geiger, Geiger, Helmut, Baer, Patrick C., Patrick C. Baer   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Molecular Cancer, 2023
Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias   +20 more
doaj   +1 more source