Results 51 to 60 of about 236,518 (260)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Relationship between the cognitive load and the learning success in applying force diagrams: eye-tracking study

Frontiers in Education
IntroductionThis paper is concerned with investigating the cognitive demands of solving force diagram tasks in different scenarios, specifically in the wind context.MethodsIn this study, students were trained using worked examples and then completed ...
Yultuz Omarbakiyeva, Larissa Hahn, Pascal Klein, Ingrid Krumphals, Bianca Watzka, Bianca Watzka   +5 more
doaj   +1 more source

THE ROLE OF STEM EDUCATION IN THE PROFESSIONAL TRAINING OF FUTURE SPECIALISTS IN ENGINEERING AND PEDAGOGICAL FIELDS [PDF]

Alfred Nobel University Journal of Pedagogy and Psychology
The article is devoted to analysing the implementation of STEM education in higher education institu- tions, aiming to develop competencies in future specialists in engineering and pedagogical fields necessary for effective activity in the context of ...
Tarasov Volodymyr, Tyutyunov Oleg
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Role of Critical Pedagogies in Early Childhood Education to Create Pathways into STEM for Racially Minoritized Communities

Education Sciences
This longitudinal study examines the long-term impact of critical pedagogy on the academic and social development of students from a marginalized Mexican American borderland community, with a specific focus on their trajectories in STEM (Science ...
Mariana Alvidrez, Jessica Rivera, Marisol Diaz   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Can STE(A)M education nurture creativity? A meta-analysis

Educational Technology & Society
Even though many experimental studies have considered nurturing creativity as an essential advantage in implementing STE(A)M (Science, Technology, Engineering, [Arts], and Mathematics) education, there is currently a lack of meta-analysis research on the
Shu-Hsuan Chang, I-Cheng Lin, Po-Jen Kuo, Chia-Chung Kuo, Tsung-Han Tsai, Pin-Chien Liu, Yan-Ling Hsu, Pei-Ling Chien
doaj   +1 more source

Using an Enhanced Video-engagement Innovation to Support STEM Teachers’ Professional Development in Technology-Based Instruction

Educational Technology & Society, 2021
This paper reports on the design, implementation, and results of a video-based study that focused on supporting an individualized viewing experience, keeping a record of what was noticed, providing a degree of guiding framework, and facilitating a ...
Oi-Lam Ng, Moonyoung Park
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source