Results 61 to 70 of about 236,518 (260)

STEM-based Artificial Intelligence Learning in General Education for Non-Engineering Undergraduate Students

Educational Technology & Society, 2021
This article describes STEM education with artificial intelligence (AI) learning, particularly for non-engineering undergraduate students. In the designed three-week learning activities, students were encouraged to put their ideas about AI into practice ...
Chun-Hung Lin, Chih-Chang Yu, Po-Kang Shih, Leon Yufeng Wu   +3 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Role of Education and Science in the Competitiveness of Russian Regions

Высшее образование в России
The relevance of this study is determined by the need to identify factors that define the role of education and science in ensuring the socio-economic development and competitiveness of Russian regions.
A. V. Shkalenko, Denis V. Naumov, E. I. Voevodina   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Students’ Perceptions of STEM: The Role of Demographic Variables and Socio-economic Status

Journal of Educational, Cultural and Psychological Studies
Students’ diminishing interest in science, technology, engineering and mathematics (STEM) courses and lack of qualified graduates in STEM fields continue to be an issuein the developing countries.
Saras Krishnan, Enriqueta D. Reston
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

A large-scale study of academic specialization and sex effects on Corsi block performance

Frontiers in Education
This study aimed to investigate the relationship between sex, educational specialization (science, technology, engineering, and mathematics (STEM) vs. non-STEM), and performance on the Corsi block-tapping task (CBT).
Sergey Malykh, Anna Pavlova, Artem Malykh, Timofey Adamovich, Tatiana Tikhomirova   +4 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

STEM AND STEAM EDUCATION IN 1st DECADE: A BIBLIOMETRIC ANALYSIS (2014-2025)

Jurnal Magister Pendidikan Matematika
STEM and STEAM education has become a strategic learning approach in addressing global challenges in the Industrial Revolution 4.0 and Society 5.0 era, focusing on developing 21st-century skills, such as creativity, critical thinking, problem-solving and
Pieter Zakarias Tupamahu, Dadan Dasari, Nanang Priatna, Nelma Dortje Lethulur   +3 more
doaj   +1 more source