Results 71 to 80 of about 1,076,552 (304)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Role of Critical Pedagogies in Early Childhood Education to Create Pathways into STEM for Racially Minoritized Communities

Education Sciences
This longitudinal study examines the long-term impact of critical pedagogy on the academic and social development of students from a marginalized Mexican American borderland community, with a specific focus on their trajectories in STEM (Science ...
Mariana Alvidrez, Jessica Rivera, Marisol Diaz   +2 more
doaj   +1 more source

Barriers to Pursuing STEM-Related Careers: Perceptions of Hispanic Girls Enrolled in Advanced High School STEM Courses [PDF]

, 2018
Researchers indicate that the United States has fallen behind other nations in science, technology, engineering, and mathematics (STEM) education (President\u27s Council of Advisors on Science and Technology, 2010, 2012).
Bustamante, Rebecca M., Combs, Julie P., Vijil, Veronica   +2 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Can STE(A)M education nurture creativity? A meta-analysis

Educational Technology & Society
Even though many experimental studies have considered nurturing creativity as an essential advantage in implementing STE(A)M (Science, Technology, Engineering, [Arts], and Mathematics) education, there is currently a lack of meta-analysis research on the
Shu-Hsuan Chang, I-Cheng Lin, Po-Jen Kuo, Chia-Chung Kuo, Tsung-Han Tsai, Pin-Chien Liu, Yan-Ling Hsu, Pei-Ling Chien
doaj   +1 more source

Using an Enhanced Video-engagement Innovation to Support STEM Teachers’ Professional Development in Technology-Based Instruction

Educational Technology & Society, 2021
This paper reports on the design, implementation, and results of a video-based study that focused on supporting an individualized viewing experience, keeping a record of what was noticed, providing a degree of guiding framework, and facilitating a ...
Oi-Lam Ng, Moonyoung Park
doaj  

STEM subjects and jobs: a longitudinal perspective of attitudes among Key Stage 3 students, 2008 - 2010 [PDF]

, 2011
The STEM Careers Awareness Timelines initiative was part of Action Programme 8 which ran between 2008 to 2011. The project was undertaken by the Centre for Education and Industry at the University of Warwick, the International Centre for Guidance Studies
Bentley, Kieran, Hutchinson, Jo
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Per a què estem a STEM? Un intent de definir l’alfabetització STEM per a tothom i amb valors. [PDF]

, 2017
L’educació STEM és una proposta emergent sobre la que se’n parla molt darrerament. Entre els investigadors/es, docents, educadors/es o  dissenyadors/es en educació STEM no hi ha, però, gaire consens més enllà de reconèixer la necessitat d’incidir en ...
Couso, Digna
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source