Results 91 to 100 of about 106,531 (314)

Nanog promotes stem-like traits of glioblastoma cells

Frontiers in Bioscience-Landmark, 2020
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in
Yuan Ye, Mengsi Zhang, Guangning Yan, Qinghua Ma, Zexuan Yan, ,Lihong Wang, Kaidi Yang, Deyu Guo   +7 more
doaj   +1 more source

Metnase regulates gene expression of stemness markers.

, 2014
Relative gene expression analysis of the stemness transcription factors NANOG, OCT3/4, and SOX2 following Metnase knockdown.
Maria Toloudi (645220), Panagiotis Apostolou (645219), Ioannis Papasotiriou (645226), Georgia Mimikakou (645222), Ioanna Vlachou (645223), Vasiliki Kipourou (645225), Eleni Kourtidou (645221), Marina Chatziioannou (645224)   +7 more
core   +1 more source

Image_3_Degree of stemness predicts micro-environmental response and clinical outcomes of diffuse large B-cell lymphoma and identifies a potential targeted therapy.eps

, 2022
Some cells within a diffuse large B-cell lymphoma (DLBCL) have the genotype of a stem cell, the proportion of which is termed degree of stemness. We interrogated correlations between the degree of stemness with immune and stromal cell scores and clinical
Lei Li (29537), Huan Li (120482), Robert Peter Gale (10333389), Fang Hu (476414), Yuanbin Song (697024), Shuiqin Chen (14071584), Yang Liang (186028)   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer [PDF]

, 2018
Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal‐like breast cancer cells.
Matsumoto, Yoshiaki, Junji Itou, Fumiaki Sato, Itou, Junji, Toi, Masakazu, Yoshiaki Matsumoto, Masakazu Toi, Sato, Fumiaki   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Predicting immunotherapeutic response and therapeutic targets by stemness classification of acute myeloid leukemia by stemness score

Discover Oncology
Objective This study aimed to investigate the role of stemness in acute myeloid leukemia (AML), stratify patients into subtypes based on stemness-associated signatures, and explore their prognostic implications as well as potential therapeutic ...
Xin Yang, Yu Zhang, Shuzhen Deng, Ying Wang, Shuli Zhao, Yujing Cheng, Chan Zhang   +6 more
doaj   +1 more source

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

Cells
Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors.
Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression

Breast Cancer Research
Background Small nucleolar RNAs (snoRNAs) play key roles in ribosome biosynthesis. However, the mechanism by which snoRNAs regulate cancer stemness remains to be fully elucidated.
Wenrong Zhang, Xinyue Song, Zining Jin, Yiqi Zhang, Shan Li, Feng Jin, Ang Zheng   +6 more
doaj   +1 more source