Results 91 to 100 of about 81,932 (265)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evaluation of 3D biomimetic microcarriers for enhancing therapeutic efficacy of human umbilical cord mesenchymal stem cells in psoriasis treatment

Frontiers in Immunology
Mesenchymal stem cells (MSCs) hold promise for regenerative medicine due to their unique biological properties, including self-renewal and multi-lineage differentiation potential.
XueMei Li, XueMei Li, YanMei Chen, JiaWei Cai, YuQiong Huang, XiangLong Chen, MingYu Yu, Li Fu, Bao Chai, Bao Chai, Cheng Zhang, ZhiYong Zhang, HongXiang Chen, HongXiang Chen   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Oncofetal dual‑specificity phosphatase 9 drives stem‐like properties through ERK1/2‐PPARG‐SCD axis‐mediated lipid metabolism in hepatocellular carcinoma

Clinical and Translational Medicine
Background Oncofetal reprogramming—the reactivation of fetal‐like gene programmes in malignant cells—has been implicated in the progression and stemness of hepatocellular carcinoma (HCC), yet its protein landscape and connection to tumour stemness remain
Wang Peng, Hai Huang, Yuchong Zhao, Qiaodan Zhou, Mengdie Cao, Luyao Liu, Jingwen Liang, Haochen Cui, Shiru Chen, Wei Chen, Si Xiong, Bin Cheng, Shuya Bai   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

mTORC1‐USP30‐LEF1 Cascade Regulates Cancer Stemness and Malignant Progression Through Mitonuclear Crosstalk

MedComm
USP30, a ubiquitin‐specific protease, primarily characterized as a mitochondrial deubiquitinase regulating mitophagy, has not been previously reported to have nuclear functions.
Xiaolin Li, Haowei Zhang, Jia Li, Cheng Luo, Zijian Yang, Jin Cai, Li Xia, Yapei Jiang, Ruonan Wang, Hongli Zeng, Yuetong Li, Haitao Yang, Tong Gao, Weidong Xie, Yaou Zhang, Naihan Xu   +15 more
doaj   +1 more source

β-hydroxybutyrate, a ketone body, suppresses tumor growth, stemness, and invasive phenotypes in non-small cell lung cancer

Cancer Biology & Therapy
Lung cancer is the most common cancer worldwide. The stemness and metastasis of tumor cells present major challenges to effective lung cancer treatment. Beta-hydroxybutyrate (BHB), a ketone body, plays a key role in various cancers.
Yunlong Huang, Jiaxuan Ding, Yufeng Zhu, Jin Shi, Rong Liu, Chunmei Wu, Liangfu Han, Mingfeng Zhang   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source