Results 111 to 120 of about 106,531 (314)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Kaohsiung Journal of Medical SciencesThe incidence and development of various tumors, such as hepatocellular carcinoma (HCC), are linked to tumor stem cells. Although research has revealed how important SCL/TAL1 interruption site (STIL) is in many human tumors, the impact of STIL on HCC ...
Zhi‐Zhong Zhang +5 more
doaj +1 more source
Targeting cellular mitophagy as a strategy for human cancers
Frontiers in Cell and Developmental BiologyMitophagy is the cellular process to selectively eliminate dysfunctional mitochondria, governing the number and quality of mitochondria. Dysregulation of mitophagy may lead to the accumulation of damaged mitochondria, which plays an important role in the
Yuming Dong, Xue Zhang
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Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a ...
Ma, Stephanie, Loh, Jia-Jian
core +1 more source
The Long Pentraxin 3 contributes to triple negative breast cancer stemness tumorigenicity.
, 2021 The Long Pentraxin 3 contributes to triple negative breast cancer stemness tumorigenicity.The Long Pentraxin 3 contributes to triple negative breast cancer stemness ...
CHURRUCA SCHUIND, ANDER
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Advanced ScienceConductive polymers (CPs) are widely studied for their ability to influence a myriad of tissue systems. While their mixed ionic/electronic conductivity is commonly considered the primary driver of these benefits, the mechanisms by which CPs influence ...
Rebecca L. Keate +5 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
CBE—Life Sciences Education, 2013 Everyone loves STEM, the acronym for science, technology, engineering, and mathematics, that sits in every call to improve U.S. competitiveness. But hidden within “science” are many different ways of thinking and acting, and unless we protect them separately, the whole scientific enterprise may be at risk.
openaire +3 more sources