Results 251 to 260 of about 177,307 (324)

A single stereogenic center matters: Development of stereodefined anti-tau PMO-gapmers. [PDF]

Mol Ther Nucleic Acids
Chen S, Poudel BH, Veedu RN.
europepmc   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

The RNA‐Puzzles Assessments of RNA‐Only Targets in CASP16

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT RNA‐Puzzles was launched in 2011 as a collaborative effort dedicated to advancing and improving RNA 3D structure prediction. The automatic evaluation protocols for comparisons between prediction and experiment developed within RNA‐Puzzles are applied to the 2024 CASP16 competition.
Eric Westhof, Hao Sun, Fan Bu, Zhichao Miao   +3 more
wiley   +1 more source

Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition. [PDF]

Beilstein J Org Chem
Ritchie BL, Longcake A, Coldham I.
europepmc   +1 more source

Secrets of a university tutor: dissection of a reaction mechanism. Part 2, the stereochemistry.

, 2012
Henry S. Rzepa
openalex   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions. [PDF]

Molecules
Zhou T, Zhang X, Sheng YJ, Zhan D, Zhang W.   +4 more
europepmc   +1 more source

Large‐Area Metallic Nanohelices for Engineering Optical Chirality

Small, EarlyView.
By exploiting the nanoscale engineering of residual stresses in metallic thin films, this method enables scalable fabrication of submicrometer metallic helices with tunable geometry and material versatility. The resulting structures exhibit pronounced chiroptical responses across the mid‐ to near‐infrared range, offering a robust platform for chiral ...
Thu Hac Huong Le, Hisako Sato, Takuo Tanaka, Dmitry Budker   +3 more
wiley   +1 more source

Correction to: Local Disordered Region Sampling (LDRS) for ensemble modeling of proteins with experimentally undetermined or low confidence prediction segments. [PDF]

Bioinformatics
europepmc   +1 more source