Results 101 to 110 of about 13,728 (257)

Alkaline‐Earth Metal Complexes Based on Tridentate β‐Diketiminate Ligands Bearing a Tethered Secondary Amine: Synthesis and Characterization

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
Deprotonotion of a β‐diketiminate ligand with a tethered secondary amine resulted in highly stable heteroleptic complexes, but the formation of the dianionic ligand could not be achieved. The alkaline‐earth (Ae) metal chemistry of a β‐diketiminate (BDI) ligand with a bulky Ar‐substituent and a pendant amine arm was investigated. The ligand precursor HC[
Bastian Rösch, Jefferson Guzmán, Heiko Bauer, Jürgen Pahl, Michael Wiesinger, Ana Escalona, Sjoerd Harder   +6 more
wiley   +1 more source

A N,N′‐p‐Tolyl Substituted Diazadiene Ligand with a Dithienylethane Backbone in Hexacoordinated Group IV Tetrachlorido Complexes—Steric Repulsions Govern the Axial Chirality Mode

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The chelating imino groups in [MCl4(DADDTEthane)] (M = Ti, Zr, Hf) give rise to a planar five‐membered (‐N=C‐C=N‐)M metallacycle. The two thiophene rings of the ligand backbone reside in a noncoplanar arrangement concerning the metallacycle, giving rise to two chiral C–C axes in the ligand backbone.
Dirk Schlüter, Daniel Duvinage, Robert Langer, Matthias Vogt   +3 more
wiley   +1 more source

Unusual backfolded binding poses of BAZ2A bromodomain binders

Acta Crystallographica Section D, EarlyView.
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove, Giulia Cazzanelli, Vito Giuseppe D'Agostino, Pablo Andres Vargas Rosales, Amedeo Caflisch, Graziano Lolli   +5 more
wiley   +1 more source

Crown Ether Stereoisomerism: Implications in Metal Ion Extraction and Ionic Liquid Design

, 2014
Since their discovery more than four decades ago, crown ethers (CEs) have been the subject of intense investigation in a number of fields. Although many of the structural features that govern the behavior of these compounds have been thoroughly explored,
Pawlak, Alan
core   +1 more source

Stereoisomerism and Equilibrium Properties of Oxygen-Carrying Cobalt(II) Complexes of Histamine and Its Derivatives:  A New Approach to an Old System

, 2016
The complex formation equilibria between pH 2 and 11.2 in Co(II)−L−O2 ternary systems (L = histamine, glycylhistamine, and sarcosylhistamine) have been studied by pH-metric, spectrophotometric, and 1H-NMR spectroscopic methods.
Jean-Jacques Delpuech (2969619), Bernard Henry (2265244), Tamás Gajda (2962176)   +2 more
core   +1 more source

Fecal Steroids as Tracers of Human Population and Waste Management Practices at the Ancient Maya City of Ucanal, Guatemala

Archaeometry, EarlyView.
ABSTRACT Geochemical data compiled from dried sediments from three water reservoirs at the ancient Maya city of Ucanal, Petén, Guatemala, reveal low to undetectable fecal biomarker concentrations. These low concentrations may be the result of the aerobic decay of sterols combined with well‐managed waste disposal practices.
Jean D. Tremblay, Peter M. J. Douglas, Christina T. Halperin, Yves Gélinas   +3 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Benign by design: A paradigm shift in cosmetic ingredient development

International Journal of Cosmetic Science, EarlyView.
Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota, Klaus Kümmerer, Isabel Martins de Almeida, Emília Sousa   +3 more
wiley   +1 more source

Digital Concept Map combined with Augmented Reality as innovative teaching material in teaching Stereoisomerism in undergraduate courses

Understanding macroscopic phenomena in Chemistry requires the mental visualization of models at the molecular level. Specifically in Organic, the lack of visuospatial skills can jeopardize the acquisition of scientific conceptual knowledge.
Azevedo, Genilson Pinheiro de, Aguiar, Joana Guilares de, Menezes, Lucas Ribeiro de   +2 more
core   +1 more source