Results 31 to 40 of about 128,311 (264)

Steric sea-level fluctuations from remote sensing, oceanic reanalyses and objective analyses in the North Atlantic

open access: yesRussian Journal of Earth Sciences, 2020
Five data sets were used to estimate steric level fluctuations in the North Atlantic for 2003-2015. We compare estimates made by a combination of altimetry and GRACE gravity data (ALT-GRV) with assessments obtained from vertical density profiles derived ...
Koldunov Aleksey   +3 more
doaj   +1 more source

Steric Effects Govern the Photoactivation of Phytochromes

open access: yesChemPhysChem, 2016
AbstractPhytochromes constitute a superfamily of photoreceptor proteins existing in two forms that absorb red (Pr) and far‐red (Pfr) light. Although it is well‐known that the conversion of Pr into Pfr (the biologically active form) is triggered by a Z→E photoisomerization of the linear tetrapyrrole chromophore, direct evidence is scarce as to why this ...
Olle Falklöf, Bo Durbeej
openaire   +4 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

An NMR Study on How Steric Effects Affect Synergistic Effects in Surfactant Mixtures

open access: yesChinese Journal of Magnetic Resonance, 2018
NMR spectra of aqueous solutions of cetyltrimethylammonium bromide (CTAB)/triton X-100 (TX-100), sodium dodecyl sulfate (SDS)/TX-100 and CTAB/TX-100/SDS surfactant mixtures were acquired.
CHEN Xiao-ying   +4 more
doaj   +1 more source

Transmission of dipolar substituent effects: ionization of a series 3-(7-substituted-1-naphthyl) propynoic acid (E)-3-(7-substituted-1-naphthyl) propenoic acids and their Esterification with Diazodiphenylmethane

open access: yesAl-Kitab Journal for Pure Sciences, 2023
Alkaline hydrolysis rates coefficients for the series of methyl 3-(7-substituted-1-naphthyl) propynoate was calculated in 70%v/v dimethylsulphoxide-water at various temperatures (25,30,40, and 50̊ C).
Khalaf D. F. Ghadir   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Bis(oxazolines) based on glycopyranosides – steric, configurational and conformational influences on stereoselectivity

open access: yesBeilstein Journal of Organic Chemistry, 2010
In previous studies we found that the asymmetric induction of bis(oxazolines) based on D-glucosamine strongly depended on the steric demand of the 3-O-substituents.
Tobias Minuth, Mike M. K. Boysen
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

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