Results 41 to 50 of about 9,364,265 (259)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Influência de efeitos estéricos na hidrólise ácida de o-alquil acetais do benzaldeído [PDF]
, 2003 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Investigação de efeitos estéricos sobre o centro reacional na hidrólise ácida de O-alquil acetais do benzaldeído ...
Belarmino, Alexanders Tadeu das Neves
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The role of steric effects on hydrogen atom transfer reactions
, 2022 We explored how steric effects influence the rate of hydrogen atom transfer (HAT) reactions between oxyradicals and alkanes. Quantum chemical computations of transition states show that activation barriers and reaction enthalpies are both influenced by ...
Sanders, Jacob N., Sun, Yi, Houk, K. N.
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Russian Journal of Earth Sciences, 2020 Five data sets were used to estimate steric level fluctuations in the North Atlantic for 2003-2015. We compare estimates made by a combination of altimetry and GRACE gravity data (ALT-GRV) with assessments obtained from vertical density profiles derived ...
Koldunov Aleksey +3 more
doaj +1 more source
Steric and Chelate Directing Effects in Aromatic Borylation
, 2016 Steric and Chelate Directing Effects in Aromatic ...
Carl N. Iverson (2981847) +2 more
core +1 more source
Steric and electronic effects on mesophase stability of segmented liquid crystalline polymers with arylazomethine pendant groups [PDF]
, 2000 The synthesis and thermotropic behavior are reported for a series of polyesters, 1, and its model compounds, 2, which bear a N-arylazomethine pendant group with para-substituents in order to evaluate electronic and steric effects on mesophase stability ...
Garay, RO +7 more
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source