Sterile inflammation in liver transplantation [PDF]
Frontiers in Medicine, 2023 Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-
Riley Kahan +6 more
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Damage-mediated macrophage polarization in sterile inflammation [PDF]
Frontiers in Immunology, 2023 Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia, neurodegenerative diseases, and many more, are associated with sterile inflammation, either as a cause or a consequence of these conditions.
Gábor Koncz +8 more
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The Role of Non-LTR Retrotransposons in Sterile Inflammation: Mechanisms and Therapeutic Potential [PDF]
BiomedicinesNon-long terminal repeat (Non-LTR) retrotransposons are mobile genetic elements that replicate through a “copy-and-paste” mechanism, enabling their expansion within the genome.
Hua Yang +8 more
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Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies [PDF]
npj Metabolic Health and DiseaseMetabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis (MASH), are major global health issues involving metabolic dysfunction, hepatic lipotoxicity, and chronic ...
Sana Raza +6 more
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SHP2‐Triggered Endothelial Cell Activation Fuels Estradiol‐Independent Endometrial Sterile Inflammation [PDF]
Advanced ScienceSterile inflammation occurs in various chronic diseases due to many nonmicrobe factors. Examples include endometrial hyperplasia (EH), endometriosis, endometrial cancer, and breast cancer, which are all sterile inflammation diseases induced by estrogen ...
Jie Pan +10 more
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HMGB1 is a mediator of cuproptosis-related sterile inflammation [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cuproptosis is a recently recognized modality of cell death driven by intracellular copper-dependent mitochondrial stress. However, the mediators of the sterile inflammatory response to cuproptotic death are undetermined.
Jiao Liu +4 more
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Distinguishing sterile inflammation from graft infection [PDF]
Journal of Cardiothoracic SurgeryWe describe the case of a 68-year-old man who underwent ascending aortic replacement and thoracic endovascular aortic repair. Four years later, the patient developed neck pain on the right side and chest computed tomography showed expansion of fluid in ...
Atsuyuki Mitsuishi +3 more
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Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma [PDF]
Frontiers in ImmunologyPeritoneal dialysis is a widely used method for treating kidney failure. However, over time, the peritoneal structure and function can deteriorate, leading to the failure of this therapy.
Hongyong Su +9 more
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Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease [PDF]
Biomedical Journal, 2023 Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ...
Sungji Cho, Fan Ying, Gary Sweeney
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Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure [PDF]
Autophagy ReportsHeart failure, a leading driver of global mortality, remains a topic of intense contemporary research interest due to the prevailing unmet need in cardiometabolic therapeutics. Numerous mechanisms with the potential to influence the onset and development
Jialing Tang +4 more
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