Results 11 to 20 of about 254,410 (141)
STING Signaling and Sterile Inflammation [PDF]
Frontiers in Immunology, 2021 Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the local environment and maintain host integrity. Besides pathogen recognition through conserved motifs, several of these receptors also sense aberrant or ...
Isabelle Couillin, Nicolas Riteau
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Sterile Inflammation in Drosophila [PDF]
Mediators of Inflammation, 2015 The study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to
Zeeshan Shaukat +2 more
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Cerebral sterile inflammation in neurodegenerative diseases [PDF]
Inflammation and Regeneration, 2020 Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms
Kento Otani, Takashi Shichita
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Gut-Derived Sterile Inflammation and Parkinson's Disease
Frontiers in Neurology, 2022 The etiology of Parkinson's disease (PD) is unknown, but evidence is increasing that there is a prominent inflammatory component to the illness. Epidemiological, genetic, and preclinical evidence support a role for gut-derived sterile inflammation.
Kathleen M. Shannon
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Sterile inflammation in laminopathies
European Journal of Cell BiologySterile inflammation, an immune response triggered in the absence of pathogens, plays a key role in various chronic diseases, including aging-related disorders, cancer, and autoimmune conditions.
Rafael Cancado de Faria, Susana Gonzalo
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Frontiers in Immunology, 2013 Inflammation is a coordinated response of the immune system which is aimed at maintaining or restoring tissue integrity. Sterile inflammation can be triggered by physical, chemical, or metabolic noxious stimuli. The individual stimuli (genomic stress, ER stress, hypoxic stress, nutrient stress, etc.) promote a carefully choreographed set of cell ...
Anna eRubartelli +3 more
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Sterile inflammation: sensing and reacting to damage [PDF]
Nature Reviews Immunology, 2010 Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors.
Grace Y, Chen, Gabriel, Nuñez
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Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury [PDF]
Frontiers in ImmunologyIntroductionPulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation.
Tomoyuki Nakagiri +14 more
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Identifying biomarkers deciphering sepsis from trauma-induced sterile inflammation and trauma-induced sepsis [PDF]
Frontiers in Immunology, 2023 ObjectiveThe purpose of this study was to identify a panel of biomarkers for distinguishing early stage sepsis patients from non-infected trauma patients.BackgroundAccurate differentiation between trauma-induced sterile inflammation and real infective ...
Praveen Papareddy +11 more
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XBP1 Facilitating NF-κB-p65 Nuclear Translocation Promotes Macrophage-Originated Sterile Inflammation Via Regulating MT2 Transcription in the Ischemia/Reperfusion LiverSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: XBP1, most conserved transcription factor of endoplasmic reticulum stress, plays important roles in physiological and pathologic settings and has profound effects on disease progression and prognosis, so it is necessary to ...
Jianhua Rao +9 more
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