Results 61 to 70 of about 91,237 (271)

Are There Sterile Neutrinos? [PDF]

, 2014
We update the hints of the existence of sterile neutrinos.
arxiv   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

STERILE NEUTRINOS AS A SOLUTION TO ALL NEUTRINO ANOMALIES [PDF]

arXiv, 1995
The sterile neutrino solutions to different irregular results and observations in neutrino physics are studied. It is pointed out that introducing sterile neutrinos helps to solve simultaneously the observed anomalies. It is argued that sterile neutrinos can solve the conflict between dark matter neutrinos, LSND result and supernova nucleosynthesis ...
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Le devoir d’enfant à l’ère de la médicalisation : stigmates, retournements et brèches en procréation assistée

Genre, Sexualité et Société, 2009
This contribution focuses on the social treatment of the childbearing duty, the stigma it can produce, as well as the paradoxes of this duty. In every society, women escaping the reproductive injunction are stigmatized in a peculiar way.
Laurence Tain
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

ORGANIZATION AND ANALYSIS OF THE COMMISSION'S WORK ON THE SELECTION AND REFERRAL OF PATIENTS IN A MEDICAL INSTITUTION FOR TREATMENT USING ASSISTED REPRODUCTIVE TECHNOLOGIES ON THE TERRITORY OF THE CHELYABINSK REGION

Фармакоэкономика, 2015
For the purpose of improvement of quality of delivery of health care to women with infertility at Ministry of Health of Chelyabinsk region the Commission on selection and the direction of patients in the medical organizations for carrying out treatment ...
M. G. Moskvicheva, V. V. Saharova, Yu. A. Semenov, E. V. Orehova   +3 more
doaj   +1 more source

A systematic map of studies testing the relationship between temperature and animal reproduction

Ecological Solutions and Evidence
Exposure to extreme temperatures can negatively affect animal reproduction, by disrupting the ability of individuals to produce any offspring (fertility), or the number of offspring produced by fertile individuals (fecundity).
Liam R. Dougherty, Fay Frost, Maarit I. Maenpaa, Melissah Rowe, Benjamin J. Cole, Ramakrishnan Vasudeva, Patrice Pottier, Eva Schultner, Erin L. Macartney, Ina Lindenbaum, Jamie L. Smith, Pau Carazo, Marco Graziano, Hester Weaving, Berta Canal Domenech, David Berger, Abhishek Meena, Tom Rhys Bishop, Daniel W. A. Noble, Pedro Simões, Julian Baur, Merel C. Breedveld, Erik I. Svensson, Lesley T. Lancaster, Jacintha Ellers, Alessio N. De Nardo, Marta A. Santos, Steven A. Ramm, Szymon M. Drobniak, Matteo Redana, Cristina Tuni, Natalie Pilakouta, Z. Valentina Zizzari, Graziella Iossa, Stefan Lüpold, Mareike Koppik, Regan Early, Clelia Gasparini, Shinichi Nakagawa, Malgorzata Lagisz, Amanda Bretman, Claudia Fricke, Rhonda R. Snook, Tom A. R. Price   +43 more
doaj   +1 more source

Sterile neutrinos? [PDF]

arXiv, 1999
The notion of sterile neutrinos is discussed. The schemes of mixing of four massive neutrinos, which imply the existence of sterile neutrinos, are briefly considered. Several model independent methods that allow to reveal possible transitions of solar neutrinos into sterile states are presented.
arxiv