Results 11 to 20 of about 503,284 (199)
Computational exploration of copper catalyzed vinylogous aerobic oxidation of unsaturated compounds
Scientific Reports, 2021 Selective oxidation is one of the most important and challenging transformations in both academic research and chemical industry. Recently, a highly selective and efficient way to synthesize biologically active γ-hydroxy-α,β-unsaturated molecules from Cu-
Ting Wang +3 more
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Molecules, 2021 In the kidney, prostaglandins formed by cyclooxygenase 1 and 2 (COX-1 and COX-2) play an important role in regulating renal blood flow. In the present study, we report our observations regarding a unique modulatory effect of renal microsomal preparation ...
Hyoung-Woo Bai +4 more
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Cryo‐EM structure of orphan G protein‐coupled receptor GPR21
MedComm, 2023 GPR21 belongs to class A orphan G protein‐coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic ...
Thian‐Sze Wong +8 more
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Clustering psychopathology in male anabolic–androgenic steroid users and nonusing weightlifters
Brain and Behavior, 2023 Introduction Prior research has demonstrated that personality disorders and clinical psychiatric syndromes are common among users of anabolic–androgenic steroids (AAS). However, the prevalence, expression, and severity of psychopathology differ among AAS
Marie Lindvik Jørstad +4 more
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Cells, 2022 Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin-producing β-cells in pancreatic islets of genetically susceptible individuals.
Bao Ting Zhu
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Steroidogenic electron-transfer factors and their diseases [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Most steroidogenesis disorders are caused by mutations in genes encoding the steroidogenic enzymes, but work in the past 20 years has identified related disorders caused by mutations in the genes encoding the cofactors that transport electrons from NADPH
Walter L. Miller
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G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Signal Transduction and Targeted Therapy, 2023 Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors.
Thian-Sze Wong +9 more
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The Scientific World JOURNAL, 2007 Glucocorticoids (GCs) are some of the most important drugs in clinical use today. They are mainly used to suppress disease-related inflammation and are widely used for the treatment of many inflammatory diseases including asthma and arthritis. However, GCs are also associated with debilitating side effects that place limitations on the long-term use of
openaire +3 more sources
Coffee intake leads to preeclampsia-like syndromes in susceptible pregnant rats
Journal of Nutritional ScienceCoffee is one of the most popular beverages worldwide, and there is an increasing concern of the health risk of coffee consumption in pregnancy. Preeclampsia (PE) is a serious pregnancy disease that causes elevated blood pressure and proteinuria in ...
Linyan Chen, Yi Duan, Pan Wang
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Cell Communication and SignalingRecently we have shown that protein disulfide isomerase (PDI or PDIA1) is involved in mediating chemically-induced, glutathione (GSH) depletion-associated ferroptotic cell death through NOS activation (dimerization) and NO accumulation. The present study
Yan-Yin Zhu +4 more
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