Results 31 to 40 of about 674,235 (211)

Subchronic exposure to tri-ortho-cresyl phosphate induces nephrotoxicity through induction of oxidative stress with neuropathy target esterase inhibition

BMC Pharmacology and Toxicology
Tri-ortho-cresyl phosphate (TOCP), an organophosphate compound widely used in industry as a lubricant, plasticizer, and hydraulic fluid, could cause organophosphate-induced delayed neuropathy (OPIDN) which is a phospholipase and involved in phospholipid ...
Jiaqi Wang, Rui Wang, Ningzhe Wu, Pan Wang   +3 more
doaj   +1 more source

Characterization of equine GST A3-3 as a steroid isomerase

, 2018
Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication by making toxic electrophiles more polar and therefore more easily excretable. However some GSTs have developed alternative functions.
Helena Lindström, Peer, Shawna M., Ing, Nancy H., Shawna M. Peer, Bengt Mannervik, Lindström, Helena,, Nancy H. Ing, Mannervik, Bengt,   +7 more
core   +1 more source

Simultaneous determination of natural and synthetic steroid estrogens and their conjugates in aqueous matrices by liquid chromatography / mass spectrometry [PDF]

, 2005
An analytical method for the simultaneous determination of nine free and conjugated steroid estrogens was developed with application to environmental aqueous matrices.
Scrimshaw, MD, Lester, JN, Gomes, RL, Birkett, JW, Scrimshaw, Mark D., Gomes, Rachel L., Birkett, Jason W., Lester, John N.   +7 more
core   +1 more source

Bazedoxifene rescues hepatocytes from chemically induced oxidative ferroptotic injury in vivo and in vitro by inhibiting protein disulfide isomerase

iScience
Summary: Acetaminophen-induced liver injury remains a major public health challenge and is characterized by glutathione depletion and oxidative stress, which are key features of oxidative ferroptosis. Protein disulfide isomerase (PDI) has been identified
Xiangyu Hao, Tian-Hao Xiao, Yi-Chen Jia, Bao Ting Zhu   +3 more
doaj   +1 more source

Coffee intake leads to preeclampsia-like syndromes in susceptible pregnant rats

Journal of Nutritional Science
Coffee is one of the most popular beverages worldwide, and there is an increasing concern of the health risk of coffee consumption in pregnancy. Preeclampsia (PE) is a serious pregnancy disease that causes elevated blood pressure and proteinuria in ...
Linyan Chen, Yi Duan, Pan Wang
doaj   +1 more source

Predicted exposures to steroid estrogens in U.K. rivers correlate with widespread sexual distruption in wild fish populations [PDF]

, 2005
Steroidal estrogens, originating principally from human excretion, are likely to play a major role in causing widespread endocrine disruption in wild populations of the roach (Rutilus rutilus) , a common cyprinid fish, in rivers contaminated by treated ...
Ronny van Aerle, Nolan, Monique, Nolan, M, Ayesha Taylor, Susan Jobling, Jobling, Susan, Jobling, S, Santos, E, Brighty, Geoff, Johnson, Andrew, Tyler, CR, Charles R. Tyler, Taylor, Ayesha, Andrew Johnson, Gross-Sorokin, M, Taylor, A, Williams, Richard, Santos, Eduarda, van Aerle, R, Richard Williams, Brighty, G, Geoff Brighty, Eduarda Santos, Williams, R, Aerle, RV, Gross-Sorokin, Melanie, Tyler, Charles R, Johnson, A, Melanie Gross-Sorokin, Monique Nolan, van Aerie, Ronny   +30 more
core   +2 more sources

Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target

Scientific Reports
Ferroptosis is a form of regulated cell death, characterized by excessive iron-dependent lipid peroxidation. Biochemically, ferroptosis can be selectively induced by erastin through glutathione depletion or through inhibition of glutathione peroxidase 4 ...
Xuanqi Huang, Ming-Jie Hou, Bao Ting Zhu
doaj   +1 more source

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Signal Transduction and Targeted Therapy, 2023
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors.
Thian-Sze Wong, Guangzhi Li, Shiliang Li, Wei Gao, Geng Chen, Shiyi Gan, Manzhan Zhang, Honglin Li, Song Wu, Yang Du   +9 more
doaj   +1 more source

Effects of Treadmill Exercise on Muscle Fibers in Mice with Steroid Myopathy. [PDF]

, 2001
We studied the effect of treadmill exercise on muscle fibers in mice with experimental steroid myopathy. Frozen sections of the extensor digitorum longus (EDL) and soleus (SOL) muscles were stained with hematoxylin-eosin, and the muscle fiber diameters ...
Watabe, Miwako, Eguchi, Katsumi, Kato, Katsutomo, Nakano, Jiro, Okita, Minoru, Yoshimura, Toshiro, Nagai, Tomoko   +6 more
core   +1 more source

Mechanism of RSL3-induced ferroptotic cell death in HT22 cells: crucial role of protein disulfide isomerase

Acta Biochimica et Biophysica Sinica
Protein disulfide isomerase (PDI) was recently shown to be an upstream mediator of erastin-induced, glutathione depletion-associated ferroptosis through its catalysis of nitric oxide synthase (NOS) dimerization
Hou Ming-Jie, Huang Xuanqi, Zhu Bao Ting
doaj   +1 more source