Results 41 to 50 of about 674,235 (211)

The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development [PDF]

, 2011
Rhodococcus equi causes fatal pyogranulomatous pneumonia in foals and immunocompromised animals and humans. Despite its importance, there is currently no effective vaccine against the disease. The actinobacteria R.
Hessels G. I., L. Dijkhuizen, Dijkhuizen, L.,, R van der Geize, Grommen A. W. F., G. I. Hessels, R. van der Geize, Grommen, A.W.F.,, L Dijkhuizen, Geize, R. van der,, Dijkhuizen, L., Hessels, G. I., A W F Grommen, Grommen, A. W. F., Jacobs, A.A.C.,, A A C Jacobs, Dijkhuizen, L.; id_orcid, A. A. C. Jacobs, Jacobs, A. A. C., Dijkhuizen L., van der Geize, R., G I Hessels, Jacobs A. A. C., Hessels, G.I.,, A. W. F. Grommen, van der Geize R.   +25 more
core   +3 more sources

Mechanism of l-Buthionine-(S,R)-sulfoximine-induced ferroptotic cell death in mouse hippocampal neuronal cells

Cell Communication and Signaling
Recent studies have revealed that accumulation of cellular nitric oxide (NO) resulting from protein disulfide isomerase (PDI)-catalyzed dimerization (i.e., catalytic activation) of nitric oxide synthase (NOS) is a pivotal upstream event in the induction ...
Yiru Wang, Xiangyu Hao, Bao Ting Zhu
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Eser, Daniela, Eser D., Baghai, Thomas C., Schule C., Romeo, Elena, Baghai T. C., Schuele, Cornelius, Rupprecht R., Rupprecht, Rainer, Eser D., Schule C., Baghai T.C., Romeo E., Rupprecht R.   +9 more
core   +1 more source

Cholesterol sulfate in human physiology: what's it all about?

Journal of Lipid Research, 2003
Cholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate.
Charles A. Strott, Yuko Higashi
doaj   +1 more source

REGULATION OF HEPATIC STEROID METABOLISM BY THE HYPOTHALAMO-PITUITARY-LIVER AXIS

, 1981
This chapter discusses the regulation of hepatic steroid metabolism by the hypothalamo-pituitary-liver axis. The pituitary gland is essential for the maintenance of the female type of steroid metabolism in the adult animal.
HÖKFELT, T, P. ENEROTH, T. HÖKFELT, NORSTEDT, G, MODE, A, GUSTAFSSON, J-Å, G. NORSTEDT, ENEROTH, P, J.-Å. GUSTAFSSON, A. MODE   +9 more
core   +1 more source

Agilent Seahorse XF HS Mini‐Platform: A Comprehensive Guide for Real‐Time Analysis of Cellular Energy Metabolism

Food Safety and Health
The Agilent Seahorse XF HS Mini‐platform enables real‐time, label‐free measurement of cellular energy metabolism by simultaneously quantifying the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR).
Zhihao Liu, Fu Zhao, Qihao Li, Jihang Chen   +3 more
doaj   +1 more source

The Anabolic Androgenic Steroid Treatment Gap: A National Study of Substance Use Disorder Treatment

Substance Abuse: Research and Treatment, 2020
Background: Anabolic androgenic steroid (AAS) use is associated with serious mental and physical health problems. Evidence indicates that AAS use among people who use psychoactive substances is higher than in the general population.
Ingrid Amalia Havnes, Marie Lindvik Jørstad, Jim McVeigh, Marie-Claire Van Hout, Astrid Bjørnebekk   +4 more
doaj   +1 more source

ADHD symptoms and use of anabolic androgenic steroids among male weightlifters

Scientific Reports, 2022
Use of anabolic androgenic steroids (AAS) is associated with adverse health effects. The factors that predispose to AAS use among athletes are poorly understood, but attention deficit/hyperactivity disorder (ADHD), which is known to occur among athletes ...
Emilie Kildal, Bjørnar Hassel, Astrid Bjørnebekk   +2 more
doaj   +1 more source

Multiplicity of 3-Ketosteroid-9α-Hydroxylase Enzymes in Rhodococcus rhodochrous DSM43269 for Specific Degradation of Different Classes of Steroids [PDF]

, 2011
The well-known large catabolic potential of rhodococci is greatly facilitated by an impressive gene multiplicity. This study reports on the multiplicity of kshA, encoding the oxygenase component of 3-ketosteroid 9α-hydroxylase, a key enzyme in steroid ...
Petrusma, Mirjan, Mirjan Petrusma, Hessels, Gerda,, Geize, Robert van der,, van der Geize, Robert, Dijkhuizen, Lubbert,, Dijkhuizen, Lubbert, Gerda Hessels, Robert van der Geize, Hessels, Gerda, Petrusma, Mirjan,, Dijkhuizen, Lubbert; id_orcid, Lubbert Dijkhuizen   +12 more
core   +4 more sources

Sodium formate-induced mitochondrial impairment and cytotoxicity in neuronal cells reveal crucial pathogenic mechanisms underlying diabetic neuropathy and retinopathy

Scientific Reports
Formic acid, a toxic one-carbon metabolite formed from methanol and formaldehyde in the body, can cause neuronal dysfunctions. It was recently hypothesized that metabolic formation of toxic one-carbon metabolites (particularly formic acid) under ...
Tian Hao Xiao, Bao Ting Zhu
doaj   +1 more source