Results 21 to 30 of about 674,235 (211)

Identification of steroid sulfate transport processes in the human mammary gland [PDF]

, 2003
Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS ...
Pizzagalli, F., Meier, P. J., Varga, Z., Huber, R. D., Folkers, G., St-Pierre, M. V.   +5 more
core   +1 more source

Metabolism of coprostanol-C14 and cholestanol-4-C14 in man

Journal of Lipid Research, 1963
Coprostanol-C14, biosynthetically prepared, was administered orally to two patients, and cholestanol-4-C14 was administered to one of them 10 months later.
R.S. Rosenfeld, Barnett Zumoff, Leon Hellman   +2 more
doaj   +1 more source

Cryo‐EM structure of orphan G protein‐coupled receptor GPR21

MedComm, 2023
GPR21 belongs to class A orphan G protein‐coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic ...
Thian‐Sze Wong, Wei Gao, Geng Chen, Chen Qiu, Guodong He, Fang Ye, Zhangsong Wu, Zicheng Zeng, Yang Du   +8 more
doaj   +1 more source

Clustering psychopathology in male anabolic–androgenic steroid users and nonusing weightlifters

Brain and Behavior, 2023
Introduction Prior research has demonstrated that personality disorders and clinical psychiatric syndromes are common among users of anabolic–androgenic steroids (AAS). However, the prevalence, expression, and severity of psychopathology differ among AAS
Marie Lindvik Jørstad, Morgan Scarth, Svenn Torgersen, Harrison Graham Pope, Astrid Bjørnebekk   +4 more
doaj   +1 more source

Mechanism underlying resveratrol’s attenuation of paclitaxel cytotoxicity in human breast cancer cells: Role of the SIRT1-FOXO1-HER3 signaling pathway

Cancer Treatment and Research Communications, 2021
: Resveratrol (RES), a dietary phenolic compound, was reported to have cancer chemoprotective and chemotherapeutic effects. Earlier we unexpectedly observed that RES has a growth-enhancing effect in some breast cancer cells and can diminish the ...
Masayuki Fukui, Hye Joung Choi, Pan Wang, Bao Ting Zhu   +3 more
doaj   +1 more source

Esterification of injected epicoprostanol in a human subject

Journal of Lipid Research, 1969
That a necessary requirement for in vivo esterification of 3-hydroxy sterols is the equatorial conformation of the hydroxyl group has been substantiated by the administration of epicoprostanol-3β-3H (3-OH equatorial) to a man with a complete biliary ...
R.S. Rosenfeld, Leon Hellman
doaj   +1 more source

Pathogenic Mechanism of Autoimmune Diabetes Mellitus in Humans: Potential Role of Streptozotocin-Induced Selective Autoimmunity against Human Islet β-Cells

Cells, 2022
Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin-producing β-cells in pancreatic islets of genetically susceptible individuals.
Bao Ting Zhu
doaj   +1 more source

3D model of amphioxus steroid receptor complexed with estradiol [PDF]

, 2009
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
Michael E. Baker, David J. Chang
core  

Protein disulfide isomerase plays a crucial role in mediating chemically-induced, glutathione depletion-associated hepatocyte injury in vitro and in vivo

Cell Communication and Signaling
Recently we have shown that protein disulfide isomerase (PDI or PDIA1) is involved in mediating chemically-induced, glutathione (GSH) depletion-associated ferroptotic cell death through NOS activation (dimerization) and NO accumulation. The present study
Yan-Yin Zhu, Qi Zhang, Yi-Chen Jia, Ming-Jie Hou, Bao Ting Zhu   +4 more
doaj   +1 more source

Strong protection by bazedoxifene against chemically-induced ferroptotic neuronal death in vitro and in vivo

Cell Communication and Signaling
Ferroptosis, a form of regulated cell death associated with glutathione depletion and excess lipid peroxidation, can be induced in cultured cells by chemicals (e.g., erastin and RSL3).
Xiangyu Hao, Yifan Wang, Ming-Jie Hou, Yong Xiao Yang, Lixi Liao, Tongxiang Chen, Pan Wang, Xiaojun Chen, Bao Ting Zhu   +8 more
doaj   +1 more source