Results 21 to 30 of about 899,028 (316)

Cryo‐EM structure of orphan G protein‐coupled receptor GPR21

MedComm, 2023
GPR21 belongs to class A orphan G protein‐coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic ...
Thian‐Sze Wong, Wei Gao, Geng Chen, Chen Qiu, Guodong He, Fang Ye, Zhangsong Wu, Zicheng Zeng, Yang Du   +8 more
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Metabolism of coprostanol-C14 and cholestanol-4-C14 in man

Journal of Lipid Research, 1963
Coprostanol-C14, biosynthetically prepared, was administered orally to two patients, and cholestanol-4-C14 was administered to one of them 10 months later.
R.S. Rosenfeld, Barnett Zumoff, Leon Hellman   +2 more
doaj   +1 more source

The fate of steroid estrogens: Partitioning during wastewater treatment and onto river sediments [PDF]

, 2010
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Springer Science+Business Media B.V.The partitioning of steroid estrogens in wastewater treatment and receiving waters is likely to ...
A Joss, A Soares, AC Johnson, AC Layton, AI Schafer, AM Robertson, AO Ifelebuegu, CE Purdom, CX Huo, Elise Cartmell, G-G Ying, JC Bowman, John N. Lester, KH Langford, KH Langford, KIE Holthaus, KM Lai, KM Lai, KM Lai, KM Lai, KU Goss, M Clara, M Hunter, M Trimmer, Mark D. Scrimshaw, MCB Braga, MD Scrimshaw, MD Scrimshaw, ND Bedding, NF Gray, OAH Jones, OAH Jones, OAH Jones, OV Martin, P Labadie, PH Dowson, PN Taylor, R Kanda, Rachel L. Gomes, RD Wauchope, RJ Williams, RL Gomes, RL Gomes, RL Gomes, RL Gomes, RP Schwarzenbach, RSK Buisson, S Jobling, S Stoveland, S Stoveland, S Stoveland, SB O’Reilly-Wiese, SB O’Reilly-Wiese, T Stephenson, TA Ternes, TY Chiu, YKK Koh, YKK Koh, YKK Koh   +58 more
core   +1 more source

Intracerebral haemorrhage in a dog with steroid-responsive meningitis arteritis [PDF]

, 2017
A one-year and six-month-old female neutered Boxer dog was presented with a four-day history of pyrexia, lethargy and neck pain. An intracerebral haemorrhage and a mediastinal mass were identified.
Brocal, Josep, Gutierrez-Quintana, Rodrigo, Hammond, Gawain, José López, Roberto   +3 more
core   +1 more source

Mechanism underlying resveratrol’s attenuation of paclitaxel cytotoxicity in human breast cancer cells: Role of the SIRT1-FOXO1-HER3 signaling pathway

Cancer Treatment and Research Communications, 2021
: Resveratrol (RES), a dietary phenolic compound, was reported to have cancer chemoprotective and chemotherapeutic effects. Earlier we unexpectedly observed that RES has a growth-enhancing effect in some breast cancer cells and can diminish the ...
Masayuki Fukui, Hye Joung Choi, Pan Wang, Bao Ting Zhu   +3 more
doaj   +1 more source

Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]

, 2016
In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven, Van Vlierberghe, Pieter   +1 more
core   +3 more sources

Pathogenic Mechanism of Autoimmune Diabetes Mellitus in Humans: Potential Role of Streptozotocin-Induced Selective Autoimmunity against Human Islet β-Cells

Cells, 2022
Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the selective loss of insulin-producing β-cells in pancreatic islets of genetically susceptible individuals.
Bao Ting Zhu
doaj   +1 more source

Clustering psychopathology in male anabolic–androgenic steroid users and nonusing weightlifters

Brain and Behavior, 2023
Introduction Prior research has demonstrated that personality disorders and clinical psychiatric syndromes are common among users of anabolic–androgenic steroids (AAS). However, the prevalence, expression, and severity of psychopathology differ among AAS
Marie Lindvik Jørstad, Morgan Scarth, Svenn Torgersen, Harrison Graham Pope, Astrid Bjørnebekk   +4 more
doaj   +1 more source

Steroid estrogen determination in sediment and sewage sludge: A critique of chromatographic / mass spectrometry methods incorporating a case study in method development [PDF]

, 2004
Current analytical methods for determining steroids in sewage sludge and sediment are reviewed and experimental data comparing LC/MS ESI and GC/MS quantification of extracts from these matrices is presented.
Avcioglu, E, Gomes, RL, Lester, JN, Scrimshaw, MD   +3 more
core   +1 more source