Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein
MedComm, 2022 GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye +10 more
doaj +1 more source
3D model of amphioxus steroid receptor complexed with estradiol [PDF]
, 2009 The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
David J. Chang, Michael E. Baker
core +2 more sources
Reduction and esterification of cholesterol and sitosterol by homogenates of feces
Journal of Lipid Research, 1971 Mixtures of cholesterol-1,2-3H and sitosterol-4-14C have been incubated with suspensions of feces in order to compare the behavior of the phytosterol with transformations known to take place with cholesterol under these conditions. Within the limitations
R.S. ROSENFELD, LEON HELLMAN
doaj +1 more source
Computational exploration of copper catalyzed vinylogous aerobic oxidation of unsaturated compounds
Scientific Reports, 2021 Selective oxidation is one of the most important and challenging transformations in both academic research and chemical industry. Recently, a highly selective and efficient way to synthesize biologically active γ-hydroxy-α,β-unsaturated molecules from Cu-
Ting Wang +3 more
doaj +1 more source
Molecules, 2021 In the kidney, prostaglandins formed by cyclooxygenase 1 and 2 (COX-1 and COX-2) play an important role in regulating renal blood flow. In the present study, we report our observations regarding a unique modulatory effect of renal microsomal preparation ...
Hyoung-Woo Bai +4 more
doaj +1 more source
Symmetric Tensor Decomposition by an Iterative Eigendecomposition Algorithm [PDF]
, 2016 We present an iterative algorithm, called the symmetric tensor eigen-rank-one iterative decomposition (STEROID), for decomposing a symmetric tensor into a real linear combination of symmetric rank-1 unit-norm outer factors using only eigendecompositions ...
Batselier, Kim, Wong, Ngai
core +3 more sources
Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate
Journal of Lipid Research, 1967 Cholesterol-3-3H,4-14C was injected intravenously in man and its transformation to cholestanol was studied. From the 3H:14C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained.
R.S. Rosenfeld +2 more
doaj +1 more source
Molecules, 2023 Neuropathy target esterase (NTE) is a serine hydrolase with phospholipase B activity, which is involved in maintaining the homeostasis of phospholipids. It can be inhibited by aging inhibitors such as some organophosphorus (OP) compounds, which leads to ...
Wenxiong Wu, Pan Wang
doaj +1 more source
Rapid bioconcentration of steroids in the plasma of three-spined stickleback Gasterosteus aculeatus exposed to waterborne testosterone and 17β-oestradiol [PDF]
, 2007 The relationship over time between the concentrations of two steroids, singly and in combination, in a static exposure system and in the blood of three-spined stickleback Gasterosteus aculeatus, held within the exposure system was investigated. Groups of
Matthiessen, P. +3 more
core +1 more source
Sex hormone-binding globulin regulation of androgen bioactivity in vivo : validation of the free hormone hypothesis [PDF]
, 2016 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues.
Antonio, Leen +15 more
core +2 more sources