Results 21 to 30 of about 503,284 (199)

Strong protection by bazedoxifene against chemically-induced ferroptotic neuronal death in vitro and in vivo

Cell Communication and Signaling
Ferroptosis, a form of regulated cell death associated with glutathione depletion and excess lipid peroxidation, can be induced in cultured cells by chemicals (e.g., erastin and RSL3).
Xiangyu Hao, Yifan Wang, Ming-Jie Hou, Yong Xiao Yang, Lixi Liao, Tongxiang Chen, Pan Wang, Xiaojun Chen, Bao Ting Zhu   +8 more
doaj   +1 more source

MIS-C Treatment: Is IVIG Always Necessary?

Frontiers in Pediatrics, 2021
Background: MIS-C is a potentially severe inflammatory syndrome associated with SARS-CoV-2 exposure. Intravenous immunoglobulin (IVIG) is considered the first-tier therapy, but it implies infusion of large fluid volumes that may worsen cardiac function ...
Francesco Licciardi, Francesco Licciardi, Letizia Baldini, Marta Dellepiane, Carlotta Covizzi, Roberta Mogni, Giulia Pruccoli, Cecilia Orsi, Ivana Rabbone, Emilia Parodi, Emilia Parodi, Federica Mignone, Federica Mignone, Davide Montin, Davide Montin   +14 more
doaj   +1 more source

ADHD symptoms and use of anabolic androgenic steroids among male weightlifters

Scientific Reports, 2022
Use of anabolic androgenic steroids (AAS) is associated with adverse health effects. The factors that predispose to AAS use among athletes are poorly understood, but attention deficit/hyperactivity disorder (ADHD), which is known to occur among athletes ...
Emilie Kildal, Bjørnar Hassel, Astrid Bjørnebekk   +2 more
doaj   +1 more source

Case Report: Need for Caution in the Diagnosis of GFAP Astrocytopathy—A Case of GFAP Astrocytopathy Coexistent With Primary Central Nervous System Lymphoma

Frontiers in Neurology, 2022
We reported a case of primary central nervous system lymphoma (PCNSL) coexistent with glial fibrillary acidic protein (GFAP) astrocytopathy, and discussed the problems needing attention in the diagnosis and differential diagnosis of GFAP astrocytopathy ...
Jia Fang, Zhongyi Tong, Wei Lu
doaj   +1 more source

The Anabolic Androgenic Steroid Treatment Gap: A National Study of Substance Use Disorder Treatment

Substance Abuse: Research and Treatment, 2020
Background: Anabolic androgenic steroid (AAS) use is associated with serious mental and physical health problems. Evidence indicates that AAS use among people who use psychoactive substances is higher than in the general population.
Ingrid Amalia Havnes, Marie Lindvik Jørstad, Jim McVeigh, Marie-Claire Van Hout, Astrid Bjørnebekk   +4 more
doaj   +1 more source

Steroids and Autoimmunity [PDF]

, 2017
From the middle of the 19th century, it is known that endocrine and immune systems interact bi-directionally in different processes that ensure organism homeostasis. Endocrine and nervous systems have a pivotal role in the balancing of pro- and anti-inflammatory functions of immune system, and constitute a complex circadian neuroendocrine network ...
TROMBETTA, AMELIA CHIARA, MERONI, MARIANNA, CUTOLO, MAURIZIO   +2 more
openaire   +3 more sources

Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target

Scientific Reports
Ferroptosis is a form of regulated cell death, characterized by excessive iron-dependent lipid peroxidation. Biochemically, ferroptosis can be selectively induced by erastin through glutathione depletion or through inhibition of glutathione peroxidase 4 ...
Xuanqi Huang, Ming-Jie Hou, Bao Ting Zhu
doaj   +1 more source

Mechanism of RSL3-induced ferroptotic cell death in HT22 cells: crucial role of protein disulfide isomerase

Acta Biochimica et Biophysica Sinica
Protein disulfide isomerase (PDI) was recently shown to be an upstream mediator of erastin-induced, glutathione depletion-associated ferroptosis through its catalysis of nitric oxide synthase (NOS) dimerization
Hou Ming-Jie, Huang Xuanqi, Zhu Bao Ting
doaj   +1 more source

Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor

Frontiers in Endocrinology, 2020
Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors.
Daniel I. Iliev, Regina Braun, Alberto Sánchez-Guijo, Michaela Hartmann, Stefan A. Wudy, Doreen Heckmann, Gernot Bruchelt, Anika Rösner, Gary Grosser, Joachim Geyer, Gerhard Binder   +10 more
doaj   +1 more source

Infection of mucormycosis inpatients in Covid-19: an experience at the tertiary medical center in Maharashtra, India

MGM Journal of Medical Sciences, 2021
Introduction: Mucormycosis is a rare infection known to be one of the most rapidly progressing and lethal forms of fungal infection in humans, with a high mortality rate of 70–100%.
Harshul Sharma, Shivaji Pole, Gaijala Sabatina, Rishika Saraf, Saurabh Joshi, Devidas Baburao Dahipale, Prassana S Mishrikotkar   +6 more
doaj   +1 more source