Unlocking Testosterone Production by Biotransformation: Engineering a Fungal Model of Aspergillus nidulans Strain Deficient in Steroid 11α-Hydroxylase Activity and Expressing 17β-Hydroxysteroid Dehydrogenase Enzyme as Proof of Concept [PDF]
BiomoleculesTestosterone holds significant medical and economic importance, with the global market for testosterone replacement therapies valued at approximately USD 1.9 billion in 2023.
Lidia Ortega-de los Ríos +6 more
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Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases [PDF]
Biotechnology for Biofuels, 2017 Background Bioethanol production from sustainable sources of biomass that limit effect on food production are needed and in a biorefinery approach co-products are desirable, obtained from both the plant material and from the microbial biomass.
Claire M. Hull +6 more
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The curious family of cytochrome P450 4F fatty acid ω-hydroxylases: recent developments in their function and relevance for human health [PDF]
Open BiologyCytochrome P450 enzymes (CYP, P450) are indispensable for human health and catalyse a plethora of reactions contributing to the clearance of xenobiotics, steroid and bile acid biosynthesis, and the functionalization of vitamins in the human body.
Brisa Caroline Alves Chagas +3 more
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Functional characterization and unraveling the structural determinants of novel steroid hydroxylase CYP154C7 from Streptomyces sp. PAMC26508 [PDF]
HeliyonThis study characterized cytochrome P450 enzyme CYP154C7 from Streptomyces sp. PAMC26508, emphasizing its capability to hydroxylate steroids, especially at the 16α-position.
Prakash Paudel +4 more
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Haplotypes of the steroid 21-hydroxylase gene region encoding mild steroid 21-hydroxylase deficiency. [PDF]
Proceedings of the National Academy of Sciences, 1991 Haplotypes of the complement 4 (C4) and steroid 21-hydroxylase [21-OHase; steroid hydrogen-donor: oxygen oxidoreductase (21-hydroxylating), EC 1.14.99.10] repeated gene complex were studied in nine families with at least one member affected with a mild form of 21-OHase deficiency.
B Haglund-Stengler +3 more
openalex +4 more sources
Identification of a Gene Encoding a New Fungal Steroid 7-Hydroxylase and Its Functional Characterization in Pichia pastoris Yeast. [PDF]
Int J Mol Sci, 2023 Kollerov V +4 more
europepmc +3 more sources
Studies on Adrenal Steroid Hydroxylases
Journal of Biological Chemistry, 1970 Tokuji Kimura +2 more
+4 more sources
Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline [PDF]
Journal of Clinical Endocrinology and Metabolism, 2018 Phyllis W Speiser +2 more
exaly +2 more sources
Bioconversion of vitamin D3 to bioactive calcifediol and calcitriol as high-value compounds
Biotechnology for Biofuels and Bioproducts, 2022 Biological catalysis is an important approach for the production of high-value-added compounds, especially for products with complex structures. Limited by the complex steps of chemical synthesis and low yields, the bioconversion of vitamin D3 (VD3) to ...
Zheyi Wang +6 more
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Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway. [PDF]
PLoS ONE, 2009 Adrenal zona fasciculata (AZF) cells express a cAMP-activated guanine nucleotide exchange protein (Epac2) that may function in ACTH-stimulated cortisol synthesis.
Judith A Enyeart, John J Enyeart
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