Results 161 to 170 of about 5,963 (192)

Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases

The Journal of Steroid Biochemistry and Molecular Biology, 2018
In the last decades, sulfonated steroids evolved from inactive metabolites intended for excretion to highly relevant compounds involved in many physiological processes. Investigations of the impact of sulfonated steroids on the steroid hormone biosynthesis revealed that, on the one hand, these can serve as substrate for steroidogenic cytochromes P450 ...
J, Neunzig, R, Bernhardt
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An Inhibitor of Adrenal Steroid 11β-Hydroxylase

Nature, 1964
Trans-1,4-bis (2-chlorobenzylaminomethyl) cyclohexane dihydrochloride (‘AY–9944’)1 has been shown to represent a novel class of cholesterol biosynthesis inhibitors which act by interfering with the enzymatic conversion of 7-dehydrocholesterol to cholesterol2,3. In laboratory animals, ‘AY–9944’ significantly depressed serum sterol-levels4.
M L, GIVNER, M, KRAML, D, DVORNIK, R, GAUDRY   +3 more
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Steroid 21-hydroxylase deficiency (congenital adrenal hyperplasia)

The American Journal of Medicine, 1995
Congenital adrenal hyperplasia, caused by any one of a number of inborn errors of steroidogenesis in which cortisol is not sufficiently produced by the adrenal cortex, is in most cases due to a deficiency of the enzyme steroid 21-hydroxylase. Classic 21-hydroxylase deficiency occurs in about 1 in 14,000 live births. In classic 21-hydroxylase deficiency,
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Genetics of steroid 21-hydroxylase deficiency

Trends in Genetics, 1985
Abstract Classical and non-classical adrenal hyperplasia due to steroid 21-hydroxylase deficiency (210HD) are HLA-linked, autosomal recessive disorders characterized by a variable degree of hyperandrogenism and cortisol deficiency. Direct screening of newborns has placed the incidence of the classical disease at 1 : 5000 to 1 : 15 000, whereas the ...
Phyllis W. Speiser, Maria I. New
openaire   +1 more source

Human saturated steroid 6alpha-hydroxylase.

The Journal of clinical endocrinology and metabolism, 1997
This study was conducted to evaluate further the reaction catalyzed by the saturated steroid 6alpha-hydroxylase of extrahepatic human tissues. Progesterone and 5alpha-dihydroprogesterone (5alpha-DHP) are plasma-borne precursors of 5alpha-pregnan-3alpha-ol-20-one, an anxiolytic/anesthetic steroid, and 5alpha-pregnan-3beta-ol-20-one in extrahepatic human
R, Dombroski, M L, Casey, P C, Macdonald
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Steroid 17α-hydroxylase of the rat adrenal

Journal of Steroid Biochemistry, 1979
Abstract The 105,000 g microsomal fraction of male or female rat adrenal contains steroid 17α-hydroxylase activity, as measured by a tritium exchange assay using 17α-[ 3 H]-pregnenolone as substrate. Administration of estrogen caused a pronounced increase in enzyme activity in the adrenals of both sexes, but the increase was greater in males. Ovine
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Steroid 21-hydroxylase deficiency

Current Opinion in Pediatrics, 1989
Perrin C. White, Christopher Crawford, Maria I. New   +2 more
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Steroid 7α-hydroxylase of rat testes

Biochemistry, 1971
H, Inano, B I, Tamaoki
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Intracellular distribution and properties of steroid 11β-hydroxylase and steroid 18-hydroxylase in rat adrenal

Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1964
Y, NAKAMURA, B, TAMAOKI
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Steroid Hydroxylases

2007
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