Characterizing the distribution of steroid sulfatase during embryonic development: when and where might metabolites of maternal steroids be reactivated? [PDF]
J Exp Biol, 2017 Paitz RT, Duffield KR, Bowden RM.
europepmc +2 more sources
IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients. [PDF]
Breast Cancer Res Treat, 2017 Palmieri C +15 more
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C‑3- and C‑4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors [PDF]
ACS Omega, 2018 Dharshini Ganeshapillai +4 more
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Development of steroid sulfatase inhibitors [PDF]
Molecular and Cellular Endocrinology, 2011 Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone-dependent cancers such as those of the breast. Considerable progress has been made in the past two decades with regard to the discovery, design and development of STS inhibitors ...
L. W. Lawrence Woo +2 more
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Cardiac arrhythmia in individuals with steroid sulfatase deficiency (X-linked ichthyosis): candidate anatomical and biochemical pathways. [PDF]
Essays BiochemWren GH, Davies W.
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Expression of Steroid Sulfatase during Embryogenesis* [PDF]
Endocrinology, 1997 Neurosteroids are steroids that are synthesized de novo in the brain from cholesterol and, in general, mediate their effects through ion-gated channel receptors such as gamma-aminobutyric acidA (GABA[A]) and N-methyl-D-aspartate receptors rather than through classical nuclear steroid hormone receptors.
Nathalie A. Compagnone +3 more
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Steroid Sulfatase Deficiency [PDF]
Pediatric Research, 1977 Placental steroid sulfatase deficiency is a genetic disorder only recently reported in the medical literature. Most documented cases of placental sulfatase deficiency have been marked by delay in onset of labor, lack of cervical dilatation, and relative refractoriness of oxytocic agents and amniotomy. We have studied the placenta, cultured fibroblasts,
L J, Shapiro +4 more
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Molecules, 2021 Steroid hormones play an essential role in a wide variety of actions in the body, such as in metabolism, inflammation, initiating and maintaining sexual differentiation and reproduction, immune functions, and stress response.
Sanna Niinivehmas, Olli T. Pentikäinen
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Post-menopausal ovarian fibroma associated with steroid hormone synthesis: A case report
Taiwanese Journal of Obstetrics & Gynecology, 2023 Objective: Ovarian fibromas are benign, sex cord-stromal tumors occurring in both peri- and post-menopausal women. Generally, these tumors are non-functional and do not produce hormones.
Naomi Sato +5 more
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Steroid Sulfation in Neurodegenerative Diseases
Frontiers in Molecular Biosciences, 2022 Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku +4 more
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