Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition [PDF]
Endocrine Reviews, 2005 Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and therefore has a pivotal role in regulating the formation of biologically active steroids. The enzyme is widely distributed throughout the body, and its action is implicated in physiological processes and pathological conditions. The crystal structure of the
Barry V. L. Potter +4 more
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Endocrinology, 2018 Steroid sulfatase (STS), a desulfating enzyme that converts steroid sulfates to hormonally active steroids, plays an important role in the homeostasis of sex hormones.
Bi Y +9 more
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Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. [PDF]
Oncol Lett, 2017 17β-estradiol (E2) can contribute to the progression of epithelial ovarian cancer (EOC). Although the majority of patients with EOC are postmenopausal woman, when de novo estrogen production in the ovary has ceased, ovarian cancer cells remain exposed to
Mungenast F +9 more
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Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy. [PDF]
Front Pharmacol, 2017 Hormone replacement therapy (HRT) affects the incidence and potential progression of colorectal cancer (CRC). As HRT primarily consists of estrone sulfate (E1S), understanding whether this conjugated estrogen is transported and metabolized in CRC will ...
Gilligan LC +6 more
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Development of an Activity‐Based Probe for Steroid Sulfatases [PDF]
ChemBioChem, 2007 the enzyme family responsiblefor the removal of the sulfate moieties from various sulfatedbiomolecules has gained considerable attention. For example,human steroid sulfatase (STS, EC 3.1.6.2) has become a targetofdrug development over the last decade due to its involve-ment in estrogen-dependent tumors.
Shih-Hsiung Wu +6 more
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Drug development research (Print), 2019 In the present work, we described convenient methods for the synthesis of N‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐sulfamates as steroid sulfatase (STS) inhibitors.
Mateusz Daśko +9 more
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Dehydroepiandrosterone sulfate stimulates expression of blood-testis-barrier proteins claudin-3 and -5 and tight junction formation via a Gna11-coupled receptor in Sertoli cells [PDF]
PLoS ONE, 2016 Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Here we show that at a physiological concentration (1 µM), DHEAS induces the phosphorylation of the kinase Erk1/2 and of the
Dietze, Raimund +4 more
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Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells. [PDF]
Oncotarget, 2017 Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.
Shin S +7 more
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Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty.
J Clin Endocrinol Metab, 2016 Context: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA. Deficient DHEA sulfation, the opposite enzymatic
Idkowiak J +11 more
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Dysregulation of STS in keratinocytes promotes calcium signaling and differentiation. [PDF]
Sci RepSteroid sulfatase (STS) is a key enzyme for the desulfation of steroid sulfates, converting them into their biologically active forms. Notably, X-linked ichthyosis (XLI), a genetic disorder characterized by hyperkeratinization, arises as a direct result ...
Kwon TU +4 more
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