Results 31 to 40 of about 3,508 (215)

Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. [PDF]

J Hepatol, 2016
Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W.   +15 more
europepmc   +3 more sources

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Nature Communications, 2021
Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.
Mercedes M. Pérez-Jiménez, José M. Monje-Moreno, Ana María Brokate-Llanos, Mónica Venegas-Calerón, Alicia Sánchez-García, Paula Sansigre, Amador Valladares, Sara Esteban-García, Irene Suárez-Pereira, Javier Vitorica, José Julián Ríos, Marta Artal-Sanz, Ángel M. Carrión, Manuel J. Muñoz   +13 more
doaj   +1 more source

Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison with drugs used in ADHD. [PDF]

Neuropsychopharmacology, 2014
Davies W, Humby T, Trent S, Eddy JB, Ojarikre OA, Wilkinson LS.   +5 more
europepmc   +3 more sources

Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. [PDF]

J Biol Chem, 2014
Jiang M, He J, Kucera H, Gaikwad NW, Zhang B, Xu M, O'Doherty RM, Selcer KW, Xie W.   +8 more
europepmc   +3 more sources

RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis

Frontiers in Molecular Biosciences, 2023
Recessive X-linked ichthyosis (RXLI), a genetic disorder caused by deletion or point mutations of the steroid sulfatase (STS) gene, is the second most common form of ichthyosis.
Farrell McGeoghan, Emanuela Camera, Miriam Maiellaro, Manasi Menon, Mei Huang, Priya Dewan, Stela Ziaj, Matthew P. Caley, Michael Donaldson, Anton J. Enright, Edel A. O’Toole, Edel A. O’Toole   +11 more
doaj   +1 more source

Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research

Metabolites, 2022
The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-
Ajna Hamidovic, Fatimata Soumare, Aamina Naveed, John Davis, Jiehuan Sun, Nhan Dang   +5 more
doaj   +1 more source

The Uptake and Deconjugation of Androstenone Sulfate in the Adipose Tissue of the Boar

Animals, 2021
Boars express high testicular levels of sulfotransferase enzymes, and consequently, the boar taint causing compound androstenone predominantly circulates as a steroid sulfate.
Christine Bone, E. James Squires
doaj   +1 more source

Profiling Urinary Sulfate Metabolites With Mass Spectrometry

Frontiers in Molecular Biosciences, 2022
The study of urinary phase II sulfate metabolites is central to understanding the role and fate of endogenous and exogenous compounds in biological systems.
Christopher C. J. Fitzgerald, Rikard Hedman, Dimanthi R. Uduwela, Bettina Paszerbovics, Adam J. Carroll, Teresa Neeman, Adam Cawley, Lance Brooker, Malcolm D. McLeod   +8 more
doaj   +1 more source

X-linked ichthyosis associated with psychosis and behavioral abnormalities: a case report

Journal of Medical Case Reports, 2017
Background X-linked ichthyosis is a dermatological condition caused by deficiency for the enzyme steroid sulfatase. Previously, X-linked ichthyosis/steroid sulfatase deficiency has been associated with developmental and neurological phenotypes.
Amna Malik, Ahmed Bait Amer, Mohammed Salama, Bander Haddad, Muhammad T. Alrifai, Mohammed Al Balwi, William Davies, Wafaa Eyaid   +7 more
doaj   +1 more source

In the Model Cell Lines of Moderately and Poorly Differentiated Endometrial Carcinoma, Estrogens Can Be Formed via the Sulfatase Pathway

Frontiers in Molecular Biosciences, 2021
Endometrial cancer (EC) is the most common gynecological malignancy in resource-abundant countries. The majority of EC cases are estrogen dependent but the mechanisms of estrogen biosynthesis and oxidative metabolism and estrogen action are not ...
Renata Pavlič, Marija Gjorgoska, Eva Hafner, Maša Sinreih, Kristina Gajser, Stefan Poschner, Walter Jäger, Tea Lanišnik Rižner   +7 more
doaj   +1 more source