Results 41 to 50 of about 3,508 (215)

Brain gene expression in a novel mouse model of postpartum mood disorder

Translational Neuroscience, 2019
Steroid sulfatase (STS) cleaves sulfate groups from steroid hormones; its expression/activity increases in late pregnancy and into the postpartum period.
Humby Trevor, Davies William
doaj   +1 more source

Steroid Sulfatase Inhibition: From Concept to Clinic and Beyond

Proceedings, 2019
Many tumours are hormone-dependent, and estrogens (E1/E2) play a key role in development.Despite aromatase inhibitor (AI) therapy [...]
Barry V L Potter
doaj   +1 more source

Chronic Exposure to 4-Nonylphenol Alters UDP-Glycosyltransferase and Sulfotransferase Clearance of Steroids in the Hard Coral, Pocillopora damicornis

Frontiers in Physiology, 2021
The effects of the xenoestrogen 4-nonylphenol (4NP) on endocrine and metabolic homeostasis in the reef building coral, Pocillopora damicornis were investigated.
Luc R. A. Rougée, Luc R. A. Rougée, Abby C. Collier, Abby C. Collier, Robert H. Richmond   +4 more
doaj   +1 more source

Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Ring A halogenated 13α-, 13β-, and 17-deoxy-13α-estrone derivatives were synthesised with N-halosuccinimides as electrophile triggers. Substitutions occurred at positions C-2 and/or C-4.
Ildikó Bacsa, Bianka Edina Herman, Rebeka Jójárt, Kevin Stefán Herman, János Wölfling, Gyula Schneider, Mónika Varga, Csaba Tömböly, Tea Lanišnik Rižner, Mihály Szécsi, Erzsébet Mernyák   +10 more
doaj   +1 more source

Steroid sulfatase [PDF]

European Journal of Biochemistry, 1986
Antibodies raised against steroid sulfatase purified from human placenta were used to follow the biosynthesis of this enzyme in human skin fibroblasts. Steroid sulfatase is synthesized as a membrane‐bound Mr‐63 500 polypeptide with asparagine‐linked oligosaccharide chains.
J, Conary, A, Nauerth, G, Burns, A, Hasilik, K, von Figura   +4 more
openaire   +2 more sources

Description of Chemical Synthesis, Nuclear Magnetic Resonance Characterization and Biological Activity of Estrane-Based Inhibitors/Activators of Steroidogenesis

Molecules, 2023
Steroid hormones play a crucial role in several aspects of human life, and steroidogenesis is the process by which hormones are produced from cholesterol using several enzymes that work in concert to obtain the appropriate levels of each hormone at the ...
Donald Poirier
doaj   +1 more source

Membrane transporters for sulfated steroids in the human testis--cellular localization, expression pattern and functional analysis. [PDF]

PLoS ONE, 2013
Sulfated steroid hormones are commonly considered to be biologically inactive metabolites, but may be reactivated by the steroid sulfatase into biologically active free steroids, thereby having regulatory function via nuclear androgen and estrogen ...
Daniela Fietz, Katharina Bakhaus, Britta Wapelhorst, Gary Grosser, Sabine Günther, Jörg Alber, Barbara Döring, Sabine Kliesch, Wolfgang Weidner, Christina E Galuska, Michaela F Hartmann, Stefan A Wudy, Martin Bergmann, Joachim Geyer   +13 more
doaj   +1 more source

Exacerbation of ichthyosis vulgaris phenotype by co-inheritance of STS and FLG mutations in a Chinese family with ichthyosis: a case report

BMC Medical Genetics, 2018
Background X-linked ichthyosis (XLI) is a recessive keratinization condition caused by deficient activity of steroid-sulfatase due to mutations in steroid sulfatase (STS) gene located on the X chromosome.
Xiong Wang, Lu Tan, Na Shen, Yanjun Lu, Ying Zhang   +4 more
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Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor

Frontiers in Endocrinology, 2020
Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors.
Daniel I. Iliev, Regina Braun, Alberto Sánchez-Guijo, Michaela Hartmann, Stefan A. Wudy, Doreen Heckmann, Gernot Bruchelt, Anika Rösner, Gary Grosser, Joachim Geyer, Gerhard Binder   +10 more
doaj   +1 more source

The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer

Frontiers in Pharmacology, 2017
Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione ...
Maša Sinreih, Tamara Knific, Maja Anko, Neli Hevir, Katja Vouk, Aleš Jerin, Snježana Frković Grazio, Tea Lanišnik Rižner   +7 more
doaj   +1 more source