Results 41 to 50 of about 452,017 (283)

Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors

European journal of medicinal chemistry, 2019
Two new piperazinyl-ureido single ring aryl sulfamate-based inhibitor series were designed against the emerging oncology drug target steroid sulfatase (STS), for which there are existing potent steroidal and non-steroidal agents in clinical trials.
Balboni, Gianfranco, Deplano, Alessandro, Foster, Paul A., Jaffri, Alisha, Moi, Davide, Onnis, Valentina, Potter, Barry V. L., Rimmer, Lucy G.   +7 more
core   +4 more sources

Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins

Molecules, 2021
Steroid hormones play an essential role in a wide variety of actions in the body, such as in metabolism, inflammation, initiating and maintaining sexual differentiation and reproduction, immune functions, and stress response.
Sanna Niinivehmas, Olli T. Pentikäinen
doaj   +1 more source

Steroid Sulfation in Neurodegenerative Diseases

Frontiers in Molecular Biosciences, 2022
Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku, Martin Hill, Lucie Kolatorova, Eva Kubala Havrdova, Radmila Kancheva   +4 more
doaj   +1 more source

Unraveling the molecular mechanisms of cell migration impairment and apoptosis associated with steroid sulfatase deficiency: Implications for X-linked ichthyosis.

Biochimica et Biophysica Acta - Molecular Basis of Disease
T. Kwon, Yeonju Kwon, H. Baek, Hyemin Park, Hyein Lee, Young-Jin Chun   +5 more
semanticscholar   +2 more sources

Inhibition of Steroid Sulfatase Activity in Endometriotic Implants by STX64 (667Coumate): A Potential New Therapy [PDF]

The Scientific World Journal, 2008
L. Fusi, A. Purohit, J. Brosens, L. W. L. Woo, B. V. L. Potter, M. J. Reed   +5 more
doaj   +2 more sources

RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis

Frontiers in Molecular Biosciences, 2023
Recessive X-linked ichthyosis (RXLI), a genetic disorder caused by deletion or point mutations of the steroid sulfatase (STS) gene, is the second most common form of ichthyosis.
Farrell McGeoghan, Emanuela Camera, Miriam Maiellaro, Manasi Menon, Mei Huang, Priya Dewan, Stela Ziaj, Matthew P. Caley, Michael Donaldson, Anton J. Enright, Edel A. O’Toole, Edel A. O’Toole   +11 more
doaj   +1 more source

High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency. [PDF]

J Lipid Res, 2015
Sánchez-Guijo A, Oji V, Hartmann MF, Schuppe HC, Traupe H, Wudy SA.   +5 more
europepmc   +3 more sources

Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research

Metabolites, 2022
The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-
Ajna Hamidovic, Fatimata Soumare, Aamina Naveed, John Davis, Jiehuan Sun, Nhan Dang   +5 more
doaj   +1 more source

Profiling Urinary Sulfate Metabolites With Mass Spectrometry

Frontiers in Molecular Biosciences, 2022
The study of urinary phase II sulfate metabolites is central to understanding the role and fate of endogenous and exogenous compounds in biological systems.
Christopher C. J. Fitzgerald, Rikard Hedman, Dimanthi R. Uduwela, Bettina Paszerbovics, Adam J. Carroll, Teresa Neeman, Adam Cawley, Lance Brooker, Malcolm D. McLeod   +8 more
doaj   +1 more source

The Uptake and Deconjugation of Androstenone Sulfate in the Adipose Tissue of the Boar

Animals, 2021
Boars express high testicular levels of sulfotransferase enzymes, and consequently, the boar taint causing compound androstenone predominantly circulates as a steroid sulfate.
Christine Bone, E. James Squires
doaj   +1 more source