The importance of steroid uptake and intracrine action in endometrial and ovarian cancers [PDF]
, 2017 Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Laczka, Csilla +2 more
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Metabolomics application in maternal-fetal medicine [PDF]
, 2013 Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant
Atzori, L +4 more
core +4 more sources
Molecules, 2023 Steroid hormones play a crucial role in several aspects of human life, and steroidogenesis is the process by which hormones are produced from cholesterol using several enzymes that work in concert to obtain the appropriate levels of each hormone at the ...
Donald Poirier
doaj +1 more source
Membrane transporters for sulfated steroids in the human testis--cellular localization, expression pattern and functional analysis. [PDF]
PLoS ONE, 2013 Sulfated steroid hormones are commonly considered to be biologically inactive metabolites, but may be reactivated by the steroid sulfatase into biologically active free steroids, thereby having regulatory function via nuclear androgen and estrogen ...
Daniela Fietz +13 more
doaj +1 more source
Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption [PDF]
arXiv, 2021 There is much concern about disruption of endocrine physiology regulated by steroid hormones in humans, other terrestrial vertebrates and fish by industrial chemicals, such as bisphenol A, and pesticides, such as DDT. These endocrine-disrupting chemicals influence steroid-mediated physiology in humans and other vertebrates by competing with steroids ...
arxiv
Post-menopausal ovarian fibroma associated with steroid hormone synthesis: A case report
Taiwanese Journal of Obstetrics & Gynecology, 2023 Objective: Ovarian fibromas are benign, sex cord-stromal tumors occurring in both peri- and post-menopausal women. Generally, these tumors are non-functional and do not produce hormones.
Naomi Sato +5 more
doaj
Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1 [PDF]
arXiv, 2023 Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response of lamprey CR1 to steroids. The DBD in
arxiv
Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies [PDF]
Pediatric Transplantation, 18(8):839-850, 2014, 2014 Interleukin-2 receptor antagonists (IL-2RA) are frequently used as induction therapy in liver transplant recipients to decrease the risk of acute rejection while allowing the reduction of concomitant immunosuppression. The exact association with the use of IL-2RA however is uncertain.
arxiv +1 more source
Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes [PDF]
, 1984 In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome.
A Chapelle de la +34 more
core +1 more source
BMC Medical Genetics, 2018 Background X-linked ichthyosis (XLI) is a recessive keratinization condition caused by deficient activity of steroid-sulfatase due to mutations in steroid sulfatase (STS) gene located on the X chromosome.
Xiong Wang +4 more
doaj +1 more source