A multivariate Bayesian learning approach for improved detection of doping in athletes using urinary steroid profiles [PDF]
arXiv, 2023 Biomarker analysis of athletes' urinary steroid profiles is crucial for the success of anti-doping efforts. Current statistical analysis methods generate personalised limits for each athlete based on univariate modelling of longitudinal biomarker values from the urinary steroid profile.
arxiv
A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis [PDF]
, 2016 Postpartum psychosis (PP) is a severe psychiatric disorder affecting a small proportion of new mothers shortly after childbirth. The molecular pathophysiology underlying the disorder is currently poorly understood, and there are no amenable animal models
Cross, Ellen S. +4 more
core +2 more sources
The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer
Frontiers in Pharmacology, 2017 Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione ...
Maša Sinreih +7 more
doaj +1 more source
Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified
Journal of Investigative Medicine High Impact Case Reports, 2020 To characterize the expression of steroidogenic enzymes implicated in the development of ovarian steroid cell tumors, not otherwise specified (SCT-NOS). We present 4 ovarian SCT-NOS evaluated by immunohistochemical staining of steroidogenic enzymes as an
Evana Valenzuela Scheker MD +8 more
doaj +1 more source
Andrology, 2020 Decreased testosterone (T) to LH ratio and increased 17β‐estradiol (E2) serum concentrations represent a common finding among patients with severe spermatogenic failure, suggesting a concurrent Leydig cell steroidogenic dysfunction.
M. Lardone +6 more
semanticscholar +1 more source
Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms. [PDF]
, 2011 Mushrooms represent an unlimited source of compounds with antitumor and immunostimulating properties and mushroom intake as been shown to reduce the risk of breast cancer.
Abreu, Rui M.V. +2 more
core +1 more source
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec [PDF]
arXiv, 2021 We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest group of jawed vertebrates. Comparison with human PR experiments provides insights into the evolution of steroid activation of human PR.
arxiv
Analysis of conjugated steroid androgens: Deconjugation, derivatisation and associated issues [PDF]
, 2009 Gas chromatography/mass spectrometry (GC/MS) is the preferred technique for the detection of urinary steroid androgens for drug testing in athletics.
Gomes, Rachel L. +3 more
core +2 more sources
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
Clinical Endocrinology, EarlyView.ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan +14 more
wiley +1 more source
Breast Cancer: Basic and Clinical Research, 2009 It is known that the steroid sulfatase (STS) and the estrogen sulfotransferase (EST1E1) are commonly expressed in human breast carcinomas. STS and EST1E1 combined action could maintain the equilibrium between sulfated (inactive) and unconjugated (active)
D. Poisson Paré +7 more
doaj +2 more sources