Results 41 to 50 of about 73,444 (214)

Steroidal Saponins from the Rhizomes of Smilax china and Their Inhibitory Effects on Lipopolysaccharide-Induced Proinflammatory Cytokines Expression

, 2022
Four new furostanol saponins (1 – 4) and a new pregane-type saponin (5) along with six known steroidal saponins (6 – 11) were isolated from the rhizomes of Smilax china.
Feng, Xiao, Cheng, Yuanyuan, Tian, Li-Wen, Li, Yu-Ting, Feng, Yunjiang   +4 more
core   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Steroidal Glycosides of Cordyline australis [PDF]

, 2006
The n-butanol extract of aerial parts of Cordyline australis demonstrated antifungal activity. n-Butanol and chloroform extracts of dried or fresh leaves of C. australis afforded a steroidal glycoside, which was identified as 5α-spirost-25(27)-en-3β-ol 3-
Korkashvili, Tamar
core  

Assignment of stereochemistry in open-chain steroidal saponins

, 2012
The major phytochemical constituents of the widely used medicinal herb Chamaelirium luteum ("false unicorn") are open-chain cholesterol-derived steroidal saponins.
Challinor, Victoria L., De Voss, James J.   +1 more
core   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

Steroidal Saponins from the Fruits of

Natural Product Communications, 2011
Seven spirostane and furostane-type glycosides were isolated from the aqueous methanolic extract of the fruits of Cestrum ruizteranianum and characterized mainly by 2D NMR spectroscopy and mass spectrometry.
Galarraga M. Elier, Anne-Claire Mitaine-Offer, Juan Manuel Amaro-Luis, Tomofumi Miyamoto, Chiaki Tanaka, Laurent Pouységu, Stéphane Quideau, Luis B. Rojas, Marie-Aleth Lacaille-Dubois   +8 more
doaj   +1 more source

Phytochemical Investigation and In Vitro Assessment of Antioxidant, Anti‐Inflammatory and Immunomodulatory Properties of Melia azedarach Linn. Extract in Chicken Lymphocyte Model

Flavour and Fragrance Journal, EarlyView.
Phytochemistry and biopotential of Melia azedarach Linn. ABSTRACT Melia azedarach Linn. (chinaberry), a medicinal plant native to tropical Asia, is a rich source of diverse bioactive compounds with reported pharmacological activities and promising therapeutic potential.
Priya Chand, Sonu Ambwani, Ravendra Kumar, Stefania Garzoli   +3 more
wiley   +1 more source

Pumpkin and chia seeds as functional foods and their application in different food products: A review

Food Biomacromolecules, EarlyView.
Abstract Functional foods have gained increasing attention for their capacity to promote health and reduce chronic‐disease risk beyond basic nutrition. Among plant‐based functional ingredients, pumpkin (Cucurbita spp.) and chia (Salvia hispanica L.) seeds are nutrient‐dense sources of proteins, unsaturated fatty acids, dietary fiber, tocopherols ...
Fatima Urooj, Fatima Javed, Abdul Mueez Ahmad, Laiba Younas, Sadia Ansar, Sumbal Raana, Muhammad Abdullah, Rimsha Amjad, Kashaf Basharat   +8 more
wiley   +1 more source

Novel steroidal saponins from Dioscorea esculenta (Togedokoro)

, 2017
Fifteen steroidal saponins 1–15, which include 4 furostanol glycosides 1–3 and 15, and 11 spirostanol glycosides 4–14, were isolated from the tubers and leaves of lesser yam (Dioscorea esculenta, Togedokoro).
Hyoung Jae Lee, Bunta Watanabe, Masaru Nakayasu, Michio Onjo, Masaharu Mizutani, Yukihiro Sugimoto   +5 more
core   +1 more source