Results 71 to 80 of about 73,444 (214)

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Antifungal Activity of C-27 Steroidal Saponins [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans , Candida glabrata
Chong-Ren, Yang, Ying, Zhang, Melissa R, Jacob, Shabana I, Khan, Ying-Jun, Zhang, Xing-Cong, Li   +5 more
openaire   +2 more sources

Advances in antitumor activity and mechanism of natural steroidal saponins: A review of advances, challenges, and future prospects [PDF]

Background: Cancer, the second leading cause of death worldwide following cardiovascular diseases, presents a formidable challenge in clinical settings due to the extensive toxic side effects associated with primary chemotherapy drugs employed for cancer
Yu, Ma, Wang, Fengge, Xue, Zheyong, Efferth, Thomas, Liang, Lu, Badar, Iftikhar Hussain, Wang, Wenjie, Zhu, Kai, Li, Dangdang, Diao, Yongchao, Li, Yanlin, Bao, Yongping, Hua, Xin, Shafi, Saba   +13 more
core   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Steroidal Saponins from the Seeds of L

Natural Product Communications, 2007
Two new furostane saponins named hamoside A and B were isolated from the 80% ethanolic extract of the defatted seeds of Trigonella hamosa L. On the basis of chemical evidence and spectral analysis (IR, 1 H NMR, 13 C NMR, HSQC, HMBC and positive ion MS ...
Arafa I. Hamed
doaj   +1 more source

Ajugol Improves Liver Fibrosis by Modulating Bile Acid and Arachidonic Acid Metabolism in Mice

Phytotherapy Research, EarlyView.
Ajujol ameliorates hepatic fibrosis by regulating bile acid metabolism and suppressing inflammatory responses. ABSTRACT Ajugol (AJ), the primary component extracted from the root of Rehmannia glutinosa, exhibits protective effects against metabolic dysregulation and chronic inflammation.
Xia Wei, Fangyuan Wang, Dingqi Zhang, Longhui Zhang, Feipeng Xu, Gaofeng Chen, Hua Zhang, Ping Liu, Wei Liu, Ying Xu   +9 more
wiley   +1 more source

Polyhydroxylated Steroidal Saponins from the Rhizomes of

Natural Product Communications, 2007
Six new polyhydroxylated spirostanol saponins ( 1 – 6 ) were isolated from the methanolic extract of the rhizomes of Convallaria majalis . On the basis of extensive spectroscopic analysis, including 2D NMR data, and a few chemical transformations, the ...
Taro Higano, Minpei Kuroda, Maki Jitsuno, Yoshihiro Mimaki   +3 more
doaj   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Two new steroidal saponins from Diuranthera inarticulata

, 2001
Two new steroidal saponins diuranthosides D and E. were isolated from the whole plant of Diuranthera inarticulata Wang et Wang et K. Y. Lang. By means of spectral and chemical analysis the structure of the new compounds were established as neotigogenin-3-
Yang, WL, Peng, SL, Zhang, Q, Tian, J, Ding, LS   +4 more
core  

Steroidal saponins from the rhizome of Polygonatum sibiricum

, 2019
Four new steroidal saponins, 3-O-β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl -(25R)-spirost-5-en-3β,17α-diol (1), 3-O-β-D-glucopyranosyl(1→4)-β-D- fucopyranosyl-(25S)-spirost-5-en-3β,17α-diol (2), 3-O-β-D-glucopyranosyl(1→2) -β-D-glucopyranosyl(1→4)-β-D ...
Sheng-An Tang (2060188), Jia Wang (51945), Ya-Ming Yu (5348039), Xiao-Dan Wu (780080), Qing-Ling Qi (5348042), Cheng Tang (439042)   +5 more
core   +1 more source