Studies of novel nitro-substituted nitrogen heterocyclic compounds [PDF]
, 2001 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The novel candidate high energy insensitive explosive; 2,5-diamino-3,6-dinitropyrazine (ANPZ-i) has been prepared in acceptable overall yield.
Philbin, Simon Patrick
core +7 more sources
Computational Evaluation of Heterocyclic Steroids: Physicochemical and Pharmacoki-netic Insights [PDF]
Records of Pharmaceutical & Biomedical SciencesCancer remains a significant global health challenge, driving the need for novel therapeutic agents with enhanced efficacy and reduced side effects.
Shadeed Gad +5 more
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Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Eser, Daniela +9 more
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Stereoselective N-Heterocyclic Carbene Catalyzed Formal [4+2] Cycloaddition: Access to Chiral Heterocyclic Cyclohexenones [PDF]
, 2022 The present study reports an asymmetric NHC-catalyzed formal [4+2] cycloaddition of heterocyclic alkenes containing polarized double bond with azolium-dienolate intermediate generated from α-bromo-α,β-unsaturated aldehydes without external oxidation of ...
Jan, Veselý +3 more
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Heterocyclic analogs of o-xylylene:a study of the synthesis and reactivity of dimethylene derivatives of thiophene and pyrrole [PDF]
, 1990 This thesis describes the chemistry of heterocyclic analogs of o-xylylene (1). o-Xylylenes are intermediates which has been used often in the synthesis of polycyclic compounds, such as ...
van den Berg, Keimpe Jan
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Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides
Angewandte Chemie, EarlyView.A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang +5 more
wiley +2 more sources
Prediction and Analysis of Active Components in Tea Stem Fermented Product Based on Network Pharmacology [PDF]
Chaye kexueTea stem has a significant impact on the sensory quality for Fucha fermentation product. To explore the active ingredients and targets of tea stems in Fucha, Aspergillus cristatus LJSC.2006 (GenBank accession number: MZ147020) was used to ferment tea ...
HE Haotian, XIAO Juanjuan, TANG Yiyu, LUO Mi, LIU Zhonghua, YU Lijun
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, 2019 A Cu(II)-catalyzed diastereoselective Michael/aldol cascade approach is used to accomplish concise total syntheses of cardiotonic steroids with varying degrees of oxygenation including cardenolides ouabagenin, sarmentologenin, 19-hydroxysarmentogenin ...
Zhongzheng Li (688422) +6 more
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Boranes in Organic Chemistry 1. О±-Carbonylalkyl- and ОІ-Oxyalkylboranes in Organic Synthesis
Eurasian Chemico-Technological Journal, 2002 This review is devoted to the synthesis of a-carbonylalkyl- and ОІ-hydroxy-alkyl boranes and their use in organic synthesis. a-Carbonyl-alkylboranes include several heteroatomic compounds, in particular, [1.2.3]-diazaborinines, uracyl boronic acids, and
V.M. Dembitsky +2 more
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