Results 31 to 40 of about 173,508 (193)

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Stereoselective N-Heterocyclic Carbene Catalyzed Formal [4+2] Cycloaddition: Access to Chiral Heterocyclic Cyclohexenones [PDF]

, 2022
The present study reports an asymmetric NHC-catalyzed formal [4+2] cycloaddition of heterocyclic alkenes containing polarized double bond with azolium-dienolate intermediate generated from α-bromo-α,β-unsaturated aldehydes without external oxidation of ...
Jan, Veselý, Ivana, Císařová, Vojtěch, Dočekal, Ladislav, Lóška   +3 more
core   +2 more sources

Protein‐Based High‐Performance Liquid Chromatography and Cyclodextrin‐Capillary Electrokinetic Chromatography for the Chiral Separation of Azoles

ELECTROPHORESIS, EarlyView.
Human serum albumin‐based high‐performance liquid chromatography and cyclodextrin‐based capillary electrokinetic chromatography were used for the chiral separation of azoles. Although only two of the five tested azoles could be enantioseparated by liquid chromatography, all of them were separated by capillary electrokinetic chromatography using single ...
Sarah Moreau, Amy Dillon, Giacomo Russo, Susanne K. Wiedmer   +3 more
wiley   +1 more source

A pd‐Catalyzed Three‐Component Approach for the Synthesis of Monomeric and Dimeric Tetrahydro‐4H‐Furo[2,3‐b]Chromene Steroids

Journal of Heterocyclic Chemistry, EarlyView.
The three‐component reaction of a steroid bearing a dihydrofuran ring, with methyl orthoformate and salicylaldehyde produced chromanketals. ABSTRACT The three‐component reaction of a steroid bearing a dihydrofuran ring, with methyl orthoformate and salicylaldehyde produced chromanketals through a [4 + 2] inverse electron demand cycloaddition ...
Juan E. Hernández‐Martínez, William H. García‐Santos, Margarita Romero‐Ávila, Marcos Flores‐Álamo, Karen M. Ruiz‐Pérez, Martín A. Iglesias‐Arteaga   +5 more
wiley   +1 more source

Malaria thriving on steroids

, 2021
Malaria causes many changes in human metabolism, although the extent to which these changes underpin pathology and the host immune response remains poorly understood. In this issue of Nature Metabolism, Abdrabou et al.
Engwerda, Christian R, McConville, Malcolm J   +1 more
core   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

DrugFacts: Anabolic steroids and other Appearance and Performance Enhancing Drugs (APEDs). [PDF]

, 2023
Anabolic steroids are synthetic, or human-made, variations of the male sex hormone testosterone. The proper term for these compounds is anabolic-androgenic steroids.

core  

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

GENERAL AND SELECTIVE ISOLATION PROCEDURES FOR GC/MS ANALYSIS OF STEROIDS IN TISSUES AND BODY FLUIDS

, 1979
Methods for isolation of steroids by filtration procedures are reviewed. Biological fluids or extracts are filtered through a series of small columns which retain either the steroids or unwanted material.
AXELSON, M, SJÖVALL, J, J. SJÖVALL, M. AXELSON   +3 more
core   +1 more source