Molecules, 2020 Although the hormone independent cytotoxic activity of several estradiol derivatives endowed with a simple substituent at C-2 has been reported so far, 2-heterocyclic and 2,3-condensed analogs are less investigated from both synthetic and pharmacological
Barnabás Molnár +4 more
doaj +1 more source
Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2Hchromen-2-one Derivatives [PDF]
, 2010 The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic ...
Ajani +47 more
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An update on the synthesis and reactivity of spiro-fused β-lactams [PDF]
, 2018 Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic ...
D'hooghe, Matthias, Dao Thi, Hang
core +1 more source
Polar Diels-Alder Reactions using Heterocycles as Electrophiles. Influence of Microwave Irradiation [PDF]
, 2015 In this work we studied a series of polar Diels-Alder reactions using different heterocycles derivatives acting as electrophiles joint to dienes of different nucleophilicity, analyzing the effect of the microwave irradiation in these processes. We employ
Della Rosa, Claudia Daniela +3 more
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Prediction and Analysis of Active Components in Tea Stem Fermented Product Based on Network Pharmacology [PDF]
Chaye kexueTea stem has a significant impact on the sensory quality for Fucha fermentation product. To explore the active ingredients and targets of tea stems in Fucha, Aspergillus cristatus LJSC.2006 (GenBank accession number: MZ147020) was used to ferment tea ...
HE Haotian, XIAO Juanjuan, TANG Yiyu, LUO Mi, LIU Zhonghua, YU Lijun
doaj +1 more source
Determination of 17α-hydroxylase-C17,20-lyase (P45017α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds [PDF]
, 2015 17α-hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment ...
Ajduković, Jovana +10 more
core +1 more source
Boranes in Organic Chemistry 1. О±-Carbonylalkyl- and ОІ-Oxyalkylboranes in Organic Synthesis
Eurasian Chemico-Technological Journal, 2002 This review is devoted to the synthesis of a-carbonylalkyl- and ОІ-hydroxy-alkyl boranes and their use in organic synthesis. a-Carbonyl-alkylboranes include several heteroatomic compounds, in particular, [1.2.3]-diazaborinines, uracyl boronic acids, and [
V.M. Dembitsky +2 more
doaj +1 more source
Mechanisms linking colorectal cancer to the consumption of (processed) red meat : a review [PDF]
, 2015 Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The vast majority of CRC cases have been linked to environmental causes rather than to heritable genetic changes.
De Smet, Stefaan +3 more
core +2 more sources
Boranes in Organic Chemistry 2. ОІ-Aminoalkyl- and ОІ-Sulfanylalkylboranes in Organic Synthesis
Eurasian Chemico-Technological Journal, 2002 Problems on using of ОІ-aminoalkyl- and ОІ-sulfanylalkylboranes in organic synthesis are considered in this review. The synthesis of boron containing a-aminoacids by Curtius rearrangement draws attention.
V.M. Dembitsky +2 more
doaj +1 more source
Gas Chromatography-Mass Spectrometry Analysis of Viburnum Opulus (L) Extract and its Toxicity Studies in Rats [PDF]
, 2017 Objectives: This study was aimed at establishing the antimicrobial and phytochemical profiles of Viburnum opulus (L) as well as the safety potential of the extract in albino Wistar rats.
Adebayo, H. A. +2 more
core +3 more sources