Results 111 to 120 of about 192,167 (361)

INSIG1 influences obesity-related hypertriglyceridemia in humans [PDF]

, 2010
In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the ...
A.H. Kissebah, Almasy, Austin, Barrett, Brown, Connelly, Cox, de Bakker, DeBose-Boyd, Diamond, Duggirala, E.K. Moses, E.M. Smith, Engelking, Forrester, Goldstein, Goring, Heller, Herbert, Horne, Horton, Horton, Hotta, J. Blangero, J.E. Curran, Kim, Kissebah, Kissebah, Kitsios, L.J. Abraham, L.J. Martin, Li, Li, Lin, M. Olivier, M.A. Carless, Malloy, Marth, Miller, Nickerson, Oki, Olivier, Olivier, Peng, Pennacchio, Pennacchio, Perusse, R. Cole, Radhakrishnan, S. Gawrieh, Shearman, Sonnenberg, T. M Baye, T.D. Dyer, Tai, Takaishi, Whitlock, Y. Zhang, Yang   +58 more
core   +2 more sources

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

La captación de colesterol por Tetrahymena thermophila se realiza principalmente por fagocitosis [PDF]

, 2018
The free-living ciliate Tetrahymena thermophila is a unicellular model organism in which landmark biological processes have been discovered, such as the first description of telomerase activity and the molecular structure of telomeres, the mechanism of ...
Cid, Nicolás Gonzalo, Elguero, María Eugenia, Favale, Nicolas Octavio, Montes, María Guadalupe, Nudel, Berta Clara, Nusblat, Alejandro David, Sánchez Granel, María Luz   +6 more
core   +1 more source

Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Poria cocos is known as an edible mushroom for food and medicine. Poria cocos and its terpenes and terpenoids serve as novel remedies to treat diabetes and its ulcers. Its mode of actions includes reduction of insulin resistance, starch digestion and inflammation as well as promotion of blood vessel formation. ABSTRACT Poria cocos is a medicinal fungus
Yi‐San Lee, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +3 more
wiley   +1 more source

Anti-Proliferative Activity of Triterpenoids and Sterols Isolated from Alstonia scholaris against Non-Small-Cell Lung Carcinoma Cells

Molecules, 2017
(1) Background: In China and South Asia, Alstonia scholaris (Apocynaceae) is an important medicinal plant that has been historically used in traditional ethnopharmacy to treat infectious diseases.
Chao-Min Wang, Shang-Jie Tsai, Yun-Lian Jhan, Kuei-Lin Yeh, Chang-Hung Chou   +4 more
doaj   +1 more source

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

A Novel Sterol from the Formosan Soft Coral <i>Lobophytum</i> Durum

, 2023
Chia‐Ling Hung, Li-Chieh Huang, Kun-Yauh Shih, Kuei-Hung Lai, Bo‐Rong Peng, Tsong‐Long Hwang, Chia‐Ying Li, Hsu‐Ming Chung   +7 more
openalex   +1 more source

Fibers as Oleogelators: Innovations, Applications, and Future Prospects in Structured Lipid Systems

Journal of the American Oil Chemists' Society, EarlyView.
Schematic overview of fiber‐based oleogelation mechanisms, processing routes, and food applications highlighting particulate/capillary structuring, polymer entanglement, and emulsion‐templated approaches. ABSTRACT Oleogels, structured oil systems created with low levels of gelators‐enables solid fat functionality while preserving the underlying liquid ...
P. Abdul Wahid, Rajni Chopra, Nitin Kumar, Monika Chand, Aishwarya Dhiman, Rajat Singh   +5 more
wiley   +1 more source